Genetic Biomarkers in the Risk Assessment of Sudden Cardiac Events: A Personalized Approach
Genetic insights into the risk assessment of sudden cardiac events. ABSTRACT Sudden cardiac events are the leading cause of death worldwide. Conventional risk stratification methods, which largely depend on clinical history, imaging, and electrocardiography, are usually inadequate for identifying high‐risk individuals, especially those without visible ...
Shrikant Verma +5 more
wiley +1 more source
Evaluating left ventricular function and myocardial fibrosis in hypertrophic obstructive cardiomyopathy with corrected myocardial work. [PDF]
Zhang X +15 more
europepmc +1 more source
Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng +3 more
wiley +1 more source
Detailed Association Between Electrocardiogram Abnormality and Primary Myocardial Fibrosis. [PDF]
Nomoto Y, Kataoka N, Imamura T.
europepmc +1 more source
Metrnl: A Novel Therapeutic Target in Atherosclerosis
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source
Small-molecule LOXL2 inhibition as a novel antifibrotic strategy for the treatment of myocardial fibrosis. [PDF]
Nadeem H, Khan WA, Mahato RK.
europepmc +1 more source
The regulation of stem cell fate and its application in neural regeneration
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He +3 more
wiley +1 more source
Noninvasive tracking of myocardial fibrosis in pressure-overload heart failure with [<sup>68</sup>Ga]Ga-FAPI-04 PET/CT. [PDF]
Liu S +11 more
europepmc +1 more source
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong +15 more
wiley +1 more source

