Results 291 to 300 of about 218,133 (348)

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source

Alogliptin Reduces Oxidative Stress in Cardiomyocytes and Ameliorates Diabetic Cardiomyopathy via the AURKB/NLGN2 Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus. This study investigated the effects of alogliptin on DCM and its underlying mechanisms. A DCM model was constructed and treated with alogliptin. Downstream targets of alogliptin were screened using bioinformatics analysis.
Li‐Jing Jiao, Jing Zhou, Jing Wang, Si‐Nan Zhao, Zhan‐Sheng Zhao, Qian Wang, Ya‐Nan Xie, Wei Jiao   +7 more
wiley   +1 more source

Effect of pirfenidone on plasma markers of collagen turnover in patients with heart failure, preserved left ventricular ejection fraction and myocardial fibrosis. [PDF]

Open Heart
Black N, Lewis G, Soltani F, Dodd S, Schelbert EB, Ravassa S, López B, González A, Cleland JG, Miller CA.   +9 more
europepmc   +1 more source

METTL14 Regulates Myocardial Infarction Progression via m6A‐Dependent Modulation of OTUD1‐Mediated Deubiquitination of DUSP6

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial infarction (MI) is the most severe clinical manifestation of coronary artery diseases (CVD) and serves as a critical driver of sudden cardiac death and heart failure (HF). Its pathophysiology begins with the abrupt cessation of coronary blood flow, leading to severe ischemia and subsequent cardiomyocyte necrosis. This study aimed to
Cheng‐Cheng Wei, Ya‐Fang Shen, Jin‐Yu Zhang   +2 more
wiley   +1 more source

Yixiao Formula Suppresses Myocardial Fibrosis Through UpregulatingmiR-133a and Downregulating TGF-<i>β</i>/Smads Signal Molecules. [PDF]

J Diabetes Res
Zhao Q, Wen Y, Wu H, Li J, Luo Y, Li P, Zhang Y, Hu C, Huang J, Zhang L, Yang X, Cui H.   +11 more
europepmc   +1 more source

Protective Effects of Riociguat Against Contrast‐Induced Nephropathy: An Experimental and Machine Learning‐Based Study in Rats

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Contrast‐induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine ...
Mustafa Begenc Tascanov, Kenan Toprak, Sibel Turedi, İsmail Koyuncu, Zulkif Tanrıverdi, Necip Fazıl Dedeoglu, Halil Fedai, Asuman Bicer, İbrahim Halil Altıparmak, Recep Demirbag, Gencay Sarıısık   +10 more
wiley   +1 more source

Ameliorating post-infarction myocardial fibrosis and cardiac function via ROS-responsive hydrogel-mediated IL-11 antibody delivery. [PDF]

Bioact Mater
You T, Zhang Y, Su H, Wang N, Zhang X, Anwaier S, Long X, Han L, Wu Y, Liang J, Yang Y, Yu C, Chen Z, Liu J, Sun T, Huang H, Zhu S, Liu N, Zhu P, Chen J, Zhuang J, Wang L, Yan X.   +22 more
europepmc   +1 more source

Baicalin protects against myocardial fibrosis through inhibition of DOT1L/COL-1 pathway during diabetic cardiomyopathy. [PDF]

Sci Rep
Xu Q, Liu Z, Wang L, Liu G, Zhao L, Yue H, Liu Y.   +6 more
europepmc   +1 more source

The Relationship between Symptom Burden and Myocardial Fibrosis in Patients with Hypertrophic Cardiomyopathy. [PDF]

Acta Cardiol Sin
Güler A, Türkmen I, Tülüce S, Aydın S, Atmaca S, Şahin H, Suna M, Gündogdu MC, Demirci G, Tekin M, Serbest NG, Türkvatan Cansever A, Ertürk M, Babur Güler G.   +13 more
europepmc   +1 more source

CCN2/CTGF-Driven Myocardial Fibrosis and NT-proBNP Synergy as Predictors of Mortality in Maintenance Hemodialysis. [PDF]

Int J Mol Sci
Ko WC, Chen CS, Chang YP, Wu CS, Yang HC, Chang JF.   +5 more
europepmc   +1 more source