Results 71 to 80 of about 1,771,410 (405)

Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators.

New England Journal of Medicine, 1992
BACKGROUND Left ventricular dilatation and dysfunction after myocardial infarction are major predictors of death. In experimental and clinical studies, longterm therapy with the angiotensin-converting--enzyme inhibitor captopril attenuated ventricular ...
M. Pfeffer, E. Braunwald, L. Moye, L. Basta, E. Brown, T. Cuddy, B. Davis, E. Geltman, S. Goldman, G. Flaker, M. Klein, G. Lamas, M. Packer, J. Rouleau, J. Rouleau, J. Rutherford, J. Wertheimer, C. Hawkins   +17 more
semanticscholar   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, Volume 15, Issue 5, Page 793-809, May 2025.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease [PDF]

, 2014
Background—Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity of the Niemann–Pick C1-like 1 (NPC1L1) protein.
The Myocardial Infarction Genetics Consortium Investigators
core   +2 more sources

High-Sensitivity Cardiac Troponin and the Universal Definition of Myocardial Infarction. [PDF]

, 2020
Background: The introduction of more sensitive cardiac troponin assays has led to increased recognition of myocardial injury in acute illnesses other than acute coronary syndrome.
Adamson, PD, Anand, A, Apple, F, Berry, C, Chapman, AR, Collinson, PO, Cruickshank, A, Ferry, AV, Findlay, I, Fox, KAA, Gray, A, High-STEACS Investigators, Keerie, C, Lee, KK, Maguire, D, McAllister, DA, Mills, NL, Newby, DE, Reid, A, Shah, ASV, Strachan, FE, Vallejos, CA, Weir, CJ   +22 more
core   +4 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]

, 2017
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco, Bordin, Antonella, Carrizzo, Albino, Chimenti, Isotta, DE FALCO, Elena, Forte, Maurizio, Frati, Giacomo, Nocella, Cristina, Pagano, Francesca, Palmerio, Silvia, Schiavon, Sonia, Schirone, Leonardo, Sciarretta, Sebastiano, Valenti, Valentina, Vecchione, Carmine, Yee, Derek   +15 more
core   +3 more sources

Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink

Arthritis Care &Research, Volume 77, Issue 5, Page 666-675, May 2025.
Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged ≥65 years. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Participants were aged ≥65 years registered with a UK general practice for at least 12 months between 1998 and 2018.
Jaspreet Kaur, Georgina Nakafero, Abhishek Abhishek, Christian Mallen, Michael Doherty, Weiya Zhang   +5 more
wiley   +1 more source

Short Sleep Duration, Obstructive Sleep Apnea, Shiftwork, and the Risk of Adverse Cardiovascular Events in Patients After an Acute Coronary Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundIt is unknown whether short sleep duration, obstructive sleep apnea, and overnight shift work are associated with the risk of recurrent cardiovascular events in patients after an acute coronary syndrome.
Laura K. Barger, Shantha M.W. Rajaratnam, Christopher P. Cannon, Mary Ann Lukas, KyungAh Im, Erica L. Goodrich, Charles A. Czeisler, Michelle L. O'Donoghue   +7 more
doaj   +1 more source

Automatic Myocardial Infarction Evaluation from Delayed-Enhancement Cardiac MRI using Deep Convolutional Networks [PDF]

arXiv, 2020
In this paper, we propose a new deep learning framework for an automatic myocardial infarction evaluation from clinical information and delayed enhancement-MRI (DE-MRI). The proposed framework addresses two tasks. The first task is automatic detection of myocardial contours, the infarcted area, the no-reflow area, and the left ventricular cavity from a
arxiv  

Serum lipid profiles in acute myocardial infarction patients in Gorgan [PDF]

, 2012
Acute myocardial infarction is one of the important reasons of death and unhealthiness in the world. The present study was undertaken to investigate the changes in serum lipids and lipoproteins in patients with acute myocardial infarction. This study was
Marjani, A., Shirafkan, A., Zaker, F.
core