Results 1 to 10 of about 1,164,371 (318)

Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis

Bioengineered, 2021
Ferroptosis is an important form of myocardial cell death in myocardial ischemia-reperfusion injury (MIRI). Naringenin (NAR), as a flavonoid, has a significant advantage in improving MIRI.
Shujun Xu, Bingxin Wu, Biying Zhong, Luoqi Lin, Yining Ding, xiao jin, Zhiwei Huang, Miaoyang Lin, Huanlin Wu, Danping Xu   +9 more
semanticscholar   +1 more source

Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments

Oxidative Medicine and Cellular Longevity, 2021
Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is currently the standard intervention. However, the reperfusion may lead to further myocardial damage, known as myocardial ischemia/reperfusion injury (MI/RI ...
M. Xiang, Yingdong Lu, Laiyun Xin, Jialiang Gao, Chang Shang, Zhilin Jiang, Hongchen Lin, Xuqin Fang, Yi Qu, Yuling Wang, Zihuan Shen, Mingjing Zhao, Xiangning Cui   +12 more
semanticscholar   +1 more source

Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis

Frontiers in Pharmacology, 2021
Baicalin is a natural flavonoid glycoside that confers protection against myocardial ischemia/reperfusion (I/R) injury. However, its mechanism has not been fully understood.
Zhenyu Fan, Liangliang Cai, Shengnan Wang, Jing Wang, Bohua Chen   +4 more
semanticscholar   +1 more source

Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury

Oxidative Medicine and Cellular Longevity, 2021
Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane ...
Wei-Kun Zhao, Yao Zhou, Tongtong Xu, Qi Wu   +3 more
semanticscholar   +1 more source

Association of Mental Stress-Induced Myocardial Ischemia With Cardiovascular Events in Patients With Coronary Heart Disease.

Journal of the American Medical Association (JAMA), 2021
Importance Mental stress-induced myocardial ischemia is a recognized phenomenon in patients with coronary heart disease (CHD), but its clinical significance in the contemporary clinical era has not been investigated.
V. Vaccarino, Z. Almuwaqqat, Jeong Hwan Kim, M. Hammadah, Amit J. Shah, Y. Ko, L. Elon, S. Sullivan, Anish S. Shah, A. Alkhoder, Bruno B. Lima, B. Pearce, L. Ward, M. Kutner, Yingtian Hu, T. Lewis, Ernest V. Garcia, J. Nye, D. Sheps, P. Raggi, J. Bremner, A. Quyyumi   +21 more
semanticscholar   +1 more source

Prevalence, Morphology, and Predictors of Intra-Stent Plaque Rupture in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study

Clinical and Applied Thrombosis/Hemostasis, 2022
Previous studies have shown that plaque rupture (PR) is the most important cause of acute coronary syndrome (ACS). However, the potential impact of intra-stent PR on stent failure manifesting as ACS and the optical coherence tomography (OCT) features of ...
Huai Yu MD, Jiannan Dai MD, Chao Fang MD, Senqing Jiang MD, Gary S. Mintz MD, Bo Yu MD   +5 more
doaj   +1 more source

Predictors of Adverse Prognosis in Patients With Acute Coronary Syndrome Caused by Plaque Erosion With a Nonstent Strategy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background The EROSION (Effective Anti‐Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography‐Based Management in Plaque Erosion) study demonstrated that antithrombotic therapy without stenting was safe and feasible in selected ...
Yanwei Yin, Fangmeng Lei, Chao Fang, Senqing Jiang, Xueming Xu, Sibo Sun, Xueying Pei, Ruyi Jia, Caiying Tang, Cong Peng, Song Li, Lulu Li, Yini Wang, Huai Yu, Jiannan Dai, Bo Yu   +15 more
doaj   +1 more source

Relationship of Microchannels and Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction: An Optical Coherence Tomography Study

Cardiology Discovery, 2022
. Objective:. Microchannels are associated with the progression of atherosclerotic vulnerable plaques. However, in patients with culprit optical coherence tomography (OCT)-defined plaque erosion, the knowledge of microchannels and culprit lesion ...
Senqing Jiang, Junchen Guo, Yanwei Yin, Chao Fang, Jifei Wang, Yidan Wang, Fangmeng Lei, Sibo Sun, Xueying Pei, Ruyi Jia, Shaotao Zhang, Lulu Li, Yini Wang, Lei Xing, Huai Yu, Huimin Liu, Maoen Xu, Xuefeng Ren, Lijia Ma, Guo Wei, Jingbo Hou, Jiannan Dai, Bo Yu, Tianyu Xu, Xiaoxia Fu   +24 more
doaj   +1 more source

Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway

Cell Death and Disease, 2021
Inducing autophagy and inhibiting apoptosis may provide a therapeutic treatment for atherosclerosis (AS). For the treatment of progressive AS, arsenic trioxide (ATO) has been used to coat vascular stents.
Shaohong Fang, Xin Wan, Xiaoyi Zou, Song Sun, Xinran Hao, Chenchen Liang, Zhenming Zhang, Fangni Zhang, Bo Sun, Hulun Li, Bo Yu   +10 more
doaj   +1 more source

Feasibility and Safety of Very-Low Contrast Combined Ringer's Solution in Optical Coherence Tomography Imaging

Frontiers in Cardiovascular Medicine, 2022
BackgroundOptical coherence tomography (OCT) is an important modality used in coronary intervention. However, OCT requires a high amount of contrast media, limiting its extensive application in clinical practice.
Tao Chen, Tao Chen, Huai Yu, Huai Yu, Lijia Ma, Lijia Ma, Chao Fang, Chao Fang, Haibo Jia, Haibo Jia, Huimin Liu, Huimin Liu, Maoen Xu, Maoen Xu, Donghui Zhang, Donghui Zhang, Guang Yang, Guang Yang, Shuangyin Zhang, Shuangyin Zhang, Jincheng Han, Jincheng Han, Guo Wei, Guo Wei, Yanchao Liu, Yanchao Liu, Jingbo Hou, Jingbo Hou, Bo Yu, Bo Yu   +29 more
doaj   +1 more source