Results 121 to 130 of about 176,278 (292)

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Anti‐Icing Organogel Enables Quasi‐Homogeneous Supercooling Preservation of Mouse Hearts

Advanced Science, EarlyView.
An organogel interface with a large energy barrier for ice nucleation is proposed to enable a quasi‐homogeneous supercooling preservation for organs. This method does not rely on cryoprotectant agents or machine perfusion and can double the ex vivo storage time of mouse hearts.
Junhao Li, Wei Wang, Chenghao Li, Lintao Kuang, Zhi Huang, Xing Chen, Zhenghao Guo, Kang Liu, Jinping Liu   +8 more
wiley   +1 more source

Enhanced Na\u3csup\u3e+\u3c/sup\u3e/H\u3csup\u3e+\u3c/sup\u3e Exchange During Ischemia and Reperfusion Impairs Mitochondrial Bioenergetics and Myocardial Function [PDF]

, 2008
Inhibition of Na+/H+ exchange (NHE) during ischemia reduces cardiac injury due to reduced reverse mode Na+/Ca2+ exchange. We hypothesized that activating NHE-1 at buffer pH 8 during ischemia increases mitochondrial oxidation, Ca2+ overload, and reactive ...
Aldakkak, Mohammed, Camara, Amadou K.S., Heisner, James S., Spence, Marisha, Stowe, David F.   +4 more
core   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Corrigendum: Higher serum phosphorus and calcium levels provide prognostic value in patients with acute myocardial infarction

Frontiers in Cardiovascular Medicine, 2022
Wei Cao, Wei Cao, Yilan Li, Yilan Li, Yao Wen, Shaohong Fang, Shaohong Fang, Bing Zhao, Bing Zhao, Xiaoyuan Zhang, Xiaoyuan Zhang, Yanxiu Zhang, Yanxiu Zhang, Xueyan Lang, Xueyan Lang, Bo Yu, Bo Yu, Yao Zhang, Yao Zhang   +18 more
doaj   +1 more source

The Safety and Efficacy of Intravascular Lithotripsy in the Treatment of Severe Coronary Artery Calcification in 261 Cases: A Retrospective Study

Health Science Reports
Background Coronary artery calcification is strongly linked to factors such as advanced age, dyslipidemia, and chronic kidney disease. Severe coronary artery calcification significantly elevates the complexity and risk of percutaneous coronary ...
Tiankun Wu, Honghui Yang, Guian Xu, Qingman Li, Lijie Zhu, Yapan Yang, Tingjie Yang   +6 more
doaj   +1 more source

Coronary artery calcification and plaque stability： an optical coherence tomography study

Heliyon, 2023
Background: Coronary artery calcification (CAC), a surrogate of atherosclerosis, is related to stent underexpansion and adverse cardiac events. However, the effect of CAC on plaque stability is still controversial and the morphological significance of ...
Zhifeng Qin, Li Yu, Yanwen Zhang, Qinglu Xu, Chao Li, Suhong Zhao, Xiangwen Xi, Yanan Tian, Zhao Wang, Jinwei Tian, Bo Yu   +10 more
doaj  

Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis

Advanced Science, EarlyView.
Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan, Xinbo Zhao, Xuejie Han, Yukai Cao, Xuexin Jin, Ling Shi, Xin Bi, Desheng Li, Yun Zhang, Wenbo Ma, Jiahui Song, Zhenwei Pan, Zhiren Zhang, Yue Li   +13 more
wiley   +1 more source

Comparative Study of Effects of Levarterenol and Methoxamine in Shock Associated with Acute Myocardial Ischemia in Dogs [PDF]

, 1962
James W. West, Arthur T. Faulk, Santiago V. Guzmán   +2 more
openalex   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source