Results 81 to 90 of about 209,868 (243)

Comprehensive age-specific metabolic phenotyping in myocardial infarction

BMC Cardiovascular Disorders
Aging is a main risk factor for the development of myocardial infarction (MI), with worse clinical outcomes. However, the understanding of age-related metabolic profiles in MI remains unclear. This study aimed to identify the clinical implications of age-
Xiaoxuan Bai, Ming Zeng, Tianyu Wu, Ying Lv, Chen Zhao, Xing Luo, Boling Yi, Huahui Ren, Yixuan Zhang, Liangxiao Xu, Xiuzhu Weng, Shan Zhang, Yuxiao Zhu, Sining Hu, Bo Yu, Haibo Jia   +15 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Impact of residual cholesterol and inflammation risk on non-culprit plaque progression in patients with acute coronary syndrome: a serial optical coherence tomography study

BMC Cardiovascular Disorders
Background Acute Coronary Syndrome (ACS) patients face recurrent cardiovascular events due to non-culprit plaque progression despite optimal secondary prevention, but the differential impacts of residual cholesterol risk (RCR, on-treatment LDL-C ≥ 1 ...
Dirui Zhang, Luping He, Boling Yi, Yishuo Xu, Chen Zhao, Ming Zeng, Yuhan Qin, Ziqian Weng, Ning Wang, Xue Feng, Lulu Li, Yini Wang, Jingbo Hou, Gary S Mintz, Sining Hu, Haibo Jia, Bo Yu   +16 more
doaj   +1 more source

Role of complement factor D in cardiovascular and metabolic diseases

Frontiers in Immunology
In the genesis and progression of cardiovascular and metabolic diseases (CVMDs), adipose tissue plays a pivotal and dual role. Complement factor D (CFD, also known as adipsin), which is mainly produced by adipocytes, is the rate-limiting enzyme of the ...
Yingjin Kong, Yingjin Kong, Naixin Wang, Naixin Wang, Zhonghua Tong, Zhonghua Tong, Dongni Wang, Dongni Wang, Penghe Wang, Penghe Wang, Qiannan Yang, Qiannan Yang, Xiangyu Yan, Xiangyu Yan, Weijun Song, Weijun Song, Zexi Jin, Zexi Jin, Maomao Zhang, Maomao Zhang   +19 more
doaj   +1 more source

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

Advanced Science, EarlyView.
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali, Mangirdas Malinauskas, Giuseppe Chirico   +2 more
wiley   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Clinical outcomes of monitored anesthesia care vs. general anesthesia in transfemoral transcatheter aortic valve implantation: a single-center retrospective study

Frontiers in Cardiovascular Medicine
BackgroundTranscatheter aortic valve implantation (TAVI) has become a preferred treatment for severe aortic stenosis in high-risk patients. In China, general anesthesia (GA) remains the standard; however, monitored anesthesia care (MAC) offers a less ...
Haoran Zhang, Haoran Zhang, Tao Chen, Tao Chen, Bo Yu, Bo Yu, Donghui Zhang, Donghui Zhang   +7 more
doaj   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Corrigendum: Higher serum phosphorus and calcium levels provide prognostic value in patients with acute myocardial infarction

Frontiers in Cardiovascular Medicine, 2022
Wei Cao, Wei Cao, Yilan Li, Yilan Li, Yao Wen, Shaohong Fang, Shaohong Fang, Bing Zhao, Bing Zhao, Xiaoyuan Zhang, Xiaoyuan Zhang, Yanxiu Zhang, Yanxiu Zhang, Xueyan Lang, Xueyan Lang, Bo Yu, Bo Yu, Yao Zhang, Yao Zhang   +18 more
doaj   +1 more source

The Safety and Efficacy of Intravascular Lithotripsy in the Treatment of Severe Coronary Artery Calcification in 261 Cases: A Retrospective Study

Health Science Reports
Background Coronary artery calcification is strongly linked to factors such as advanced age, dyslipidemia, and chronic kidney disease. Severe coronary artery calcification significantly elevates the complexity and risk of percutaneous coronary ...
Tiankun Wu, Honghui Yang, Guian Xu, Qingman Li, Lijie Zhu, Yapan Yang, Tingjie Yang   +6 more
doaj   +1 more source