Results 261 to 270 of about 159,601 (304)
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Adjuncts to Thrombolysis for Myocardial Reperfusion
Annals of Internal Medicine, 1991To discuss adjunctive pharmacologic agents for acute myocardial infarction, to critique their initial effects in clinical trials, and to review their potential for improving the clinical conditions of patients with acute myocardial infarction.Relevant studies reported from January 1985 to December 1990 were identified through a MEDLINE search of the ...
J J, Popma, E J, Topol
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ACUTE INTERVENTIONS FOR MYOCARDIAL REPERFUSION
Emergency Medicine Clinics of North America, 1998The primary goal of treatment in acute myocardial infarction is reperfusion of the infarct-related artery in as short a time as possible. Present strategies for acute reperfusion include the use of thrombolytic agents and a variety of catheter-based interventions.
M, Brown +3 more
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Mechanisms of myocardial reperfusion injury
The Annals of Thoracic Surgery, 1999Reperfusion of the ischemic myocardium results in irreversible tissue injury and cell necrosis, leading to decreased cardiac performance. While early reperfusion of the heart is essential in preventing further tissue damage due to ischemia, reintroduction of blood flow can expedite the death of vulnerable, but still viable, myocardial tissue, by ...
J L, Park, B R, Lucchesi
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Apoptosis in Myocardial Ischemia‐Reperfusion
Annals of the New York Academy of Sciences, 1999Abstract: The signal transduction pathways by which ischemia‐reperfusion leads to apoptosis may involve the JNK pathway, ceramide generation, and inhibition of protective PKC pathways. The biochemical events associated with apoptosis include mitochondrial inactivation, cytochrome c dislocation, caspase activation, and cytoplasmic acidification ...
R A, Gottlieb, R L, Engler
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Critical Care Nursing Clinics of North America, 1990
A review of the mechanism of ischemic-reperfusion injury, proposed interventions to prevent injury, and future directions have been presented to enhance the practitioner's knowledge of this new, exciting concept in myocardial injury. There is increasing evidence in the literature that reperfusion injury may occur in other organ systems and is ...
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A review of the mechanism of ischemic-reperfusion injury, proposed interventions to prevent injury, and future directions have been presented to enhance the practitioner's knowledge of this new, exciting concept in myocardial injury. There is increasing evidence in the literature that reperfusion injury may occur in other organ systems and is ...
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Myocardial Protection During Reperfusion
The Thoracic and Cardiovascular Surgeon, 1996After prolonged periods of energy depletion, myocardial cells may rapidly deteriorate during the early stage of reperfusion. It has now been clearly demonstrated that this kind of acute lethal reperfusion injury is due to specific processes elicited by cellular re-energization.
H M, Piper +3 more
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Myocardial Preservation: Controlled Reperfusion
Seminars in Thoracic and Cardiovascular Surgery, 2011Reperfusion injury after reestablishing coronary flow by releasing the aortic cross clamp after cardiac surgery with cardioplegic arrest causes myocardial damage and even death. Attenuation of this reperfusion response by controlling the biochemical and physical environment can avoid morbidity and mortality.
Prasanna Simha, Mohan Rao +1 more
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Myocardial protection in reperfusion with postconditioning
Expert Review of Cardiovascular Therapy, 2005Reperfusion is the definitive treatment for coronary occlusive disease. However, reperfusion carries the potential to exacerbate lethal injury, termed 'reperfusion injury'. Studies have suggested that reperfusion injury events are triggered during the early moments of reflow, and determine, in part, the severity of downstream manifestations of ...
Jakob, Vinten-Johansen +3 more
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Neutrophils and myocardial reperfusion injury
Pharmacology & Therapeutics, 1996Ischaemia induces an acute inflammatory response in myocardial tissue with an early phase of neutrophil accumulation, which is accelerated by reperfusion. In experimental models, interventions that deplete neutrophils or inhibit their function cause a significant reduction in myocardial infarct size. These cells, therefore, may exacerbate tissue injury
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Myocardial ischemia and reperfusion injury
Cardiovascular Pathology, 2005Myocardial ischemic injury results from severe impairment of coronary blood supply and produces a spectrum of clinical syndromes. As a result of intensive investigation over decades, a detailed understanding is now available of the complexity of the response of the myocardium to an ischemic insult.
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