Results 31 to 40 of about 105,760 (306)

Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size [PDF]

, 2021
Aims: Identifying novel mediators of lethal myocardial reperfusion injury that can be targeted during primary percutaneous coronary intervention (PPCI) is key to limiting the progression of patients with ST-elevated myocardial infarction (STEMI) to ...
Mangion, Kenneth, Lee, Mathew MY, Channon, Keith M, Good, Richard, Rocchiccioli, Paul, Nicklin, Stuart A., He, Weihong, Loughrey, Christopher M., Shaukat, Aadil, Petrie, Mark C, Elliott, Elspeth B, Nicklin, Stuart A, Channon, Keith M., Hood, Stuart, Nather, Katrin, Smith, Godfrey L, Elliott, Elspeth B., Carrick, David, Lee, Mathew M.Y., Davie, Andrew, O’Toole, Dylan, Lee, Mathew M Y, McCarroll, Charlotte S., Hawksby, Catherine, Loughrey, Christopher M, Petrie, Mark C., Oldroyd, Keith G., McArthur, Lisa, Martin, Tamara, McEntegart, Margaret, McClure, John, Smith, Godfrey L., Berry, Colin, Zaeri, Ali, Oldroyd, Keith G, Riddell, Alexandra, O'Toole, Dylan, Lindsay, Mitchell M., McCarroll, Charlotte S, Corcoran, David, Watkins, Stuart, Lindsay, Mitchell M, Eteiba, Hany, Ford, Kristopher   +43 more
core   +1 more source

Long noncoding RNA FTX ameliorates hydrogen peroxide-induced cardiomyocyte injury by regulating the miR-150/KLF13 axis

Open Life Sciences, 2020
Myocardial reperfusion is an effective therapy for acute myocardial infarction (AMI). However, ischemia/reperfusion (I/R) injury following myocardial reperfusion is a significant limitation for AMI treatment.
Zhang Yamin, Fan Xiaoying, Yang Hua
doaj   +1 more source

Device‐Based Approaches Targeting Cardioprotection in Myocardial Infarction: The Expanding Armamentarium of Innovative Strategies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Coronary reperfusion therapy has played a pivotal role for reducing mortality and heart failure after acute myocardial infarction. Although several adjunctive approaches have been studied for reducing infarct size further, both ischemia–reperfusion ...
Francisco José Romeo, Renata Mazurek, Tomoki Sakata, Spyros A. Mavropoulos, Kiyotake Ishikawa   +4 more
doaj   +1 more source

Modelling myocardial ischaemia and reperfusion

Progress in Biophysics and Molecular Biology, 1998
Substrate depletion and increased intracellular acidity are believed to underlie clinically important manifestations of myocardial ischaemia. Recent advances in measuring ion concentrations and metabolite changes have provided a wealth of detail on the processes involved.
F F, Ch'en, R D, Vaughan-Jones, K, Clarke, D, Noble   +3 more
openaire   +2 more sources

The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus

Neural Regeneration Research, 2017
Myocardial ischemia/reperfusion injury can lead to severe brain injury. Glycogen synthase kinase 3 beta is known to be involved in myo-cardial ischemia/reperfusion injury and diabetes mellitus. However, the precise role of glycogen synthase kinase 3 beta
Bo Zhao, Wen-wei Gao, Ya-jing Liu, Meng Jiang, Lian Liu, Quan Yuan, Jia-bao Hou, Zhong-yuan Xia   +7 more
doaj   +1 more source

Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury [PDF]

, 2010
HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium. It remains unclear whether other HDL-associated sphingophospholipids have similar effects.
Bodo Levkau, Levkau, Bodo, Herrgott, Ilka, Johanning, Kai, Echtermeyer, Frank, Chun, Jerold, Hildebrand, Reinhard, Ilka Herrgott, Gregor Theilmeier, Christine Herzog, Winterhalter, Michael, Frank Ulrich Müller, Schmitz, Martina, Müller, Frank Ulrich, Jan Mersmann, Michael Winterhalter, Reinhard Hildebrand, Martina Schmitz, Herzog, Christine, Frank Echtermeyer, Jerold Chun, Theilmeier, Gregor, Mersmann, Jan, Larmann, Jan, Jan Larmann, Kai Johanning   +25 more
core   +1 more source

Cardioprotection and Myocardial Reperfusion [PDF]

Circulation Research, 2013
With the advent of thrombolytic therapy and angioplasty, it has become possible to reduce myocardial infarct size through early reperfusion. Enormous effort has been expended to find therapies that can further reduce infarct size after early intervention.
Richard S, Vander Heide, Charles, Steenbergen   +1 more
openaire   +2 more sources

The pathophysiology of myocardial reperfusion: a pathologist’s perspective [PDF]

Heart, 2006
Coronary artery thrombosis, caused either by fissuring or erosion of atherosclerotic plaques, is the usual cause of acute myocardial infarction.1 If a coronary occlusion persists for more than 30 minutes, irreversible damage to the myocardium occurs. Persistent coronary occlusion results in a progressive increase of the infarct size with a wave-front ...
BASSO, CRISTINA, THIENE, GAETANO
openaire   +3 more sources

Disparate effects of adhesion and degranulation of platelets on myocardial and coronary function in postischaemic hearts [PDF]

, 1998
Beside the major effect of acute thrombus formation, little is known about the interaction of platelets with the coronary endothelium in an ischaemia–reperfusion situation.
Welsch, Ulrich, Heindl, Bernhard, Zahler, Stefan, Becker, Bernhard F.   +3 more
core   +1 more source

Cardioprotective Effect of Nec-1 in Rats Subjected to MI/R: Downregulation of Autophagy-Like Cell Death

Cardiovascular Therapeutics, 2021
Objective. Necrostatin-1 (Nec-1), an inhibitor of necroptosis, has been reported to protect against myocardial ischemia-reperfusion (MI/R) injury. However, the contribution of the potential antinecroptotic effect of Nec-1 on its infarct limitation and ...
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu   +5 more
doaj   +1 more source