Results 221 to 230 of about 131,479 (353)

Mitochondrial Transfer in the Tumor Microenvironment

Cancer Science, EarlyView.
Mitochondria are actively exchanged among tumor, immune, stromal, and neuronal cells within the tumor microenvironment. Such transfer rewires tumor metabolism, promotes immune evasion, and drives therapy resistance. Targeting mitochondrial transfer or harnessing mitochondrial transplantation represents a promising strategy to restore antitumor immunity
Ryo Omae, Takamasa Ishino, Yosuke Togashi   +2 more
wiley   +1 more source

Additional file 5 of Preventive and therapeutic effects of ginsenosides on myocardial ischemia-reperfusion injury in animal models: a systematic review and meta-analysis

Hongyi Yue, Yunfei Jia, Ruohao Sun, Zhuoyang Song, Wenhua Li   +4 more
openalex   +1 more source

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Initial Despair and Current Hope of Identifying a Clinically Useful Treatment of Myocardial Reperfusion Injury: Insights Derived from Studies of Platelet P2Y₁₂ Antagonists and Interference with Inflammation and NLRP3 Assembly. [PDF]

Int J Mol Sci
Cohen MV, Downey JM.
europepmc   +1 more source

Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats [PDF]

, 2012
Xiaozheng Zhong
openalex   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, EarlyView.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Total saponins from Trillium Tschonoskii Maxim alleviate myocardial ischemia reperfusion injury in rat [PDF]

, 2020
Xiujing Zhang, Wei Wang, Jie Tang, Qin Xie, Di Ma   +4 more
openalex   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Prognostic Impact of New‐Onset Atrial Fibrillation After Cardiac Arrest: Observations From a Federated Research Network

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Data on adverse events in patients developing atrial fibrillation (AF) after cardiac arrest (CA) are limited. Methods Retrospective analysis using the TriNetX network. Adults (≥ 18 years) with CA (ICD‐10‐CM I46) from 2014 to 2024 were divided into two cohorts: those with new‐onset AF (I48) within 2 days after CA and those without ...
Enrico Tartaglia, Tommaso Bucci, Amir Askarinejad, Michele Rossi, Muath Alobaida, Steven Ho Man Lam, Mert Kaskal, Andrea Galeazzo Rigutini, Shir Lynn Lim, Giuseppe Boriani, Gregory Y. H. Lip   +10 more
wiley   +1 more source