Results 311 to 320 of about 131,479 (353)

Perioperative myocardial ischemia reperfusion injury

Anesthesiology Clinics of North America, 2003
Myocardial I-R injury contributes to adverse cardiovascular outcomes after cardiac surgery. The pathogenesis of I-R injury is complex and involves the activation, coordination, and amplification of several systemic and local proinflammatory pathways (Fig. 4).
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Neutrophils and myocardial reperfusion injury

Pharmacology & Therapeutics, 1996
Ischaemia induces an acute inflammatory response in myocardial tissue with an early phase of neutrophil accumulation, which is accelerated by reperfusion. In experimental models, interventions that deplete neutrophils or inhibit their function cause a significant reduction in myocardial infarct size. These cells, therefore, may exacerbate tissue injury
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Connexin43 and Myocardial Ischemia-Reperfusion Injury

Cardiovascular & Hematological Disorders-Drug Targets, 2018
Recently, the treatment and prevention of ischemic cardiomyopathy is one of the emerging research topics in the cardiovascular field. Gap junction is the basic structure of cardiac electrophysiology. Connexin is the basic unit of gap junctions. Connexin43(CX43) is the most abundant member of Cx family in the heart, the normal expression of Cx43 is ...
Lingyun, Zu, Ningxin, Wen, Changjie, Liu, Mingming, Zhao, Lemin, Zheng   +4 more
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Myocardial ischemia and reperfusion injury

Cardiovascular Pathology, 2005
Myocardial ischemic injury results from severe impairment of coronary blood supply and produces a spectrum of clinical syndromes. As a result of intensive investigation over decades, a detailed understanding is now available of the complexity of the response of the myocardium to an ischemic insult.
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Pharmacological therapy for myocardial reperfusion injury

Current Opinion in Pharmacology, 2004
In the ischemic myocardium, reperfusion is necessary for the salvage of cells and cardiac function. However, reperfusion itself causes 'reperfusion injury', leading to the damage of myocardial cells. This is reduced by several interventions, as measured by the limitation of infarct size or reduction of arrhythmias.
George V, Moukarbel, Chakib M, Ayoub, Antoine B, Abchee   +2 more
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Reperfusion injury, stunning and myocardial viability

Australian and New Zealand Journal of Medicine, 1993
Abstract:Recent experimental data suggest that current thrombolytic strategies may not yet have achieved their full potential for myocardial salvage. In fact, reperfusion may result in microvascular and myocardial cellular injuries. These may translate into transient loss of contractile function (‘myocardial stunning’), and possibly contribute to the ...
A, Tonkin, R, Chan
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C5aR-mediated myocardial ischemia/reperfusion injury

Biochemical and Biophysical Research Communications, 2007
The complement system activation can mediate myocardial ischemia and reperfusion (I/R). Inhibition of C5a activity reveals attenuation of I/R-induced myocardial infarct size. However, the contribution of C5a receptor (C5aR) to I/R injury remains to be unknown.
Haimou, Zhang, Gangjian, Qin, Gang, Liang, Jinan, Li, Robert A, Barrington, Dong-Xu, Liu   +5 more
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Zinc and myocardial ischemia/reperfusion injury

BioMetals, 2013
As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors.
Zhelong, Xu, Juan, Zhou
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Lethal Myocardial Reperfusion Injury

2012
Early coronary artery reperfusion reduces infarct size and mortality and improves left ventricular contractile performance after myocardial ischemia compared to permanent occlusion. However, reperfusion itself causes either an acceleration of injury that is not present during ischemia or causes de novo reversible and lethal injury to heart tissue.
Jakob Vinten-Johansen, Amanda J. Zatta, Rong Jiang, Weiwei Shi   +3 more
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Clarithromycin attenuates myocardial ischemia–reperfusion injury

Expert Opinion on Therapeutic Targets, 2010
MMP activity is upregulated in the heart after myocardial ischemia reperfusion, and its activation contributes to the changes in left ventricular (LV) dysfunction. A major macrolide antibiotic, clarithromycin has many biological functions including MMP regulation.
Takuya, Nakajima, Keiichi, Hishikari, Masahito, Ogawa, Ryo, Watanabe, Jun-ichi, Suzuki, Ayako, Nagashima, Mayumi, Masumura, Kiyoshi, Takayama, Yasunobu, Hirata, Ryozo, Nagai, Mitsuaki, Isobe   +10 more
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