Results 311 to 320 of about 285,668 (333)

Reperfusion injury, stunning and myocardial viability

Australian and New Zealand Journal of Medicine, 1993
Abstract:Recent experimental data suggest that current thrombolytic strategies may not yet have achieved their full potential for myocardial salvage. In fact, reperfusion may result in microvascular and myocardial cellular injuries. These may translate into transient loss of contractile function (‘myocardial stunning’), and possibly contribute to the ...
A, Tonkin, R, Chan
openaire   +2 more sources

C5aR-mediated myocardial ischemia/reperfusion injury

Biochemical and Biophysical Research Communications, 2007
The complement system activation can mediate myocardial ischemia and reperfusion (I/R). Inhibition of C5a activity reveals attenuation of I/R-induced myocardial infarct size. However, the contribution of C5a receptor (C5aR) to I/R injury remains to be unknown.
Haimou, Zhang, Gangjian, Qin, Gang, Liang, Jinan, Li, Robert A, Barrington, Dong-Xu, Liu   +5 more
openaire   +2 more sources

Zinc and myocardial ischemia/reperfusion injury

BioMetals, 2013
As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors.
Zhelong, Xu, Juan, Zhou
openaire   +2 more sources

Lethal Myocardial Reperfusion Injury

2012
Early coronary artery reperfusion reduces infarct size and mortality and improves left ventricular contractile performance after myocardial ischemia compared to permanent occlusion. However, reperfusion itself causes either an acceleration of injury that is not present during ischemia or causes de novo reversible and lethal injury to heart tissue.
Jakob Vinten-Johansen, Amanda J. Zatta, Rong Jiang, Weiwei Shi   +3 more
openaire   +1 more source

Clarithromycin attenuates myocardial ischemia–reperfusion injury

Expert Opinion on Therapeutic Targets, 2010
MMP activity is upregulated in the heart after myocardial ischemia reperfusion, and its activation contributes to the changes in left ventricular (LV) dysfunction. A major macrolide antibiotic, clarithromycin has many biological functions including MMP regulation.
Takuya, Nakajima, Keiichi, Hishikari, Masahito, Ogawa, Ryo, Watanabe, Jun-ichi, Suzuki, Ayako, Nagashima, Mayumi, Masumura, Kiyoshi, Takayama, Yasunobu, Hirata, Ryozo, Nagai, Mitsuaki, Isobe   +10 more
openaire   +2 more sources

The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy

Basic Research in Cardiology, 2021
Hualu Zhang, Ningzhi Yang, Haiyan He, Junwu Chai, Xinxin Cheng, Huanhuan Zhao, Dongming Zhou, T. Teng, Xiangrong Kong, Qing Yang, Zhelong Xu   +10 more
semanticscholar   +1 more source

Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6

Journal of Pineal Research, 2020
Targeting mitochondrial quality control with melatonin has been found promising for attenuating diabetic cardiomyopathy (DCM), although the underlying mechanisms remain largely undefined.
Liming Yu, Xue Dong, Xiaodong Xue, Shu-hua Xu, Xu Zhang, Yinli Xu, Zhishang Wang, Yang Wang, Hao Gao, Yangzhi Liang, Yang Yang, Huishan Wang   +11 more
semanticscholar   +1 more source

Unresolved issues in myocardial reperfusion injury

Cardiovascular Pathology, 2010
While the basic pathobiology of myocardial ischemic injury and reperfusion has been determined over the last 50 years, there are important, unresolved, or at least not completely elucidated, issues in the field. These include the relative contributions of different modes of cell injury and death to evolving myocardial infarcts; interactions of ...
Louis Maximilian, Buja, Priya, Weerasinghe   +1 more
openaire   +2 more sources

Myocardial Reperfusion Injury: The Critical Challenge

Critical Care Nursing Clinics of North America, 1992
Oxygen-free radical production and reperfusion injury are complex mechanisms. New and improved methods for maximizing the benefits of reperfusion while minimizing reperfusion injury are on the horizon in the 1990s. Critical care nurses play a crucial role in the assessment, planning, and intervention of patients experiencing the deleterious effects of ...
V J, Coombs, L, Black, S N, Townsend
openaire   +2 more sources

Melatonin attenuates myocardial ischemia‐reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK‐OPA1 signaling pathways

Journal of Pineal Research, 2019
Optic atrophy 1 (OPA1)‐related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1‐related mitochondrial fusion/mitophagy is activated by melatonin and ...
Y. Zhang, Yue Wang, Junnan Xu, F. Tian, Shunying Hu, Yundai Chen, Zhenhong Fu   +6 more
semanticscholar   +1 more source