Results 61 to 70 of about 68,817 (283)

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

Myocyte-specific overexpressing HDAC4 promotes myocardial ischemia/reperfusion injury

Molecular Medicine, 2018
Background Histone deacetylases (HDACs) play a critical role in modulating myocardial protection and cardiomyocyte survivals. However, Specific HDAC isoforms in mediating myocardial ischemia/reperfusion injury remain currently unknown.
Ling Zhang, Hao Wang, Yu Zhao, Jianguo Wang, Patrycja M. Dubielecka, Shougang Zhuang, Gangjian Qin, Y Eugene Chin, Race L. Kao, Ting C. Zhao   +9 more
doaj   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source

Senkyunolide I Improves Septicemia‐Induced Brain Dysfunction via Regulating Nrf2 and Astrocyte Activity.

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Senkyunolide I (Sen I) has a protective effect on the blood–brain barrier (BBB) in rats with sepsis‐associated encephalopathy (SAE). This study investigated whether Sen I regulates Nrf2 to ameliorate sepsis‐induced brain dysfunction (SIBD). Sixty rats were randomly assigned into Sham group, SAE group (Model group), SAE + Sen I group (72 mg/kg,
Haohao Cao, Tao Liu, Meixia Xu
wiley   +1 more source

Increased Thrombogenicity is Associated With Coronary Microvascular Dysfunction in Patients With STEMI—A Proof‐of‐Concept Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Up to 50% of patients with ST‐segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) develop coronary microvascular dysfunction (CMD). Aims This study aims to assess whether a prothrombotic state of coronary blood, defined by thromboelastography (TEG), is associated with post ...
Roberto Scarsini, Denis Leonardi, Andrea Bottardi, Concetta Mammone, Leonardo Portolan, Caterina Butturini, Verdiana Galli, Francesco Della Mora, Alessandro Ruzzarin, Sara Pazzi, Anna Piccoli, Simone Fezzi, Domenico Tavella, Gabriele Pesarini, Leonardo Gottin, Flavio Ribichini   +15 more
wiley   +1 more source

Treatment With Phosphodiesterase 5 Inhibitors and Long‐Term Outcomes in Patients Undergoing Coronary Angiography and Cardiac Catheterization

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The effects of phosphodiesterase 5 (PDE5) inhibitors on the incidence of long‐term outcomes in patients with cardiovascular disease are not well understood. Objective: We studied the association between PDE5 inhibitor therapy and the incidence of adverse cardiovascular major adverse cardiovascular events (MACE) in patients ...
Sumon Roy, Annette Min, Edward O. McFalls, Robert A. Perera, Fadi N. Salloum, Ion S. Jovin   +5 more
wiley   +1 more source

Electrocardiographic R Wave Peak Time: Correlation With the Severity of Coronary Artery Disease and Prognosis in Patients With Acute Coronary Syndrome

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Electrocardiographic parameters have emerged as valuable noninvasive markers for risk stratification in acute coronary syndrome (ACS). Aims This study aimed to evaluate the correlation between R wave peak time (RWPT) and coronary artery disease (CAD) severity, and to assess its prognostic value for in‐hospital major adverse cardiac ...
Jilin Xu, Wen Yu, Xiuqi Li, Xingan Wu, Baozhen Tan, Jing Han   +5 more
wiley   +1 more source

Detection of Myocardial Ischemia-Reperfusion Injury Using a Fluorescent Near-Infrared Zinc(II)-Dipicolylamine Probe and Tc Glucarate

Molecular Imaging, 2012
A fluorescent zinc 2,2′-dipicolylamine coordination complex PSVue®794 (probe 1) is known to selectively bind to phosphatidylserine exposed on the surface of apoptotic and necrotic cells.
Leonie wyffels, Brian D. Gray, Christy Barber, Koon Y. Pak, Safiyyah Forbes, Jeffrey A. Mattis, James M. Woolfenden, Zhonglin Liu   +7 more
doaj   +1 more source