Results 101 to 110 of about 337,957 (243)
Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue
iNew Medicine, EarlyView.ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao +3 more
wiley +1 more source
Genetic Biomarkers in the Risk Assessment of Sudden Cardiac Events: A Personalized Approach
iNew Medicine, EarlyView.Genetic insights into the risk assessment of sudden cardiac events. ABSTRACT Sudden cardiac events are the leading cause of death worldwide. Conventional risk stratification methods, which largely depend on clinical history, imaging, and electrocardiography, are usually inadequate for identifying high‐risk individuals, especially those without visible ...
Shrikant Verma +5 more
wiley +1 more source
Understanding and interpreting composite outcomes in clinical research
Journal of Hospital Medicine, EarlyView.Abstract Composite outcomes combine multiple endpoints into a single measure. They can capture overall treatment effects and increase statistical power, but have important interpretive challenges. Components of the outcome may vary in clinical importance, frequency, and treatment effect.
Mari Takashima +3 more
wiley +1 more source
Iron-mediated radical reactions upon reperfusion contribute to myocardial "stunning"
, 1990 Recent evidence suggests that postischemic myocardial dysfunction ("stunning") is mediated by iron-catalyzed free radical reactions, but the exact time window during which the critical iron-mediated damage develops remains unknown.
X. Y. Li +6 more
core +1 more source
Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report
Journal of Pharmacy Practice and Research, EarlyView.Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring +3 more
wiley +1 more source
Perioperative Risks of Concurrent Pancreatic and Hepatic Resections for Neuroendocrine Tumors
Journal of Surgical Oncology, EarlyView.ABSTRACT Background and Objectives Pancreatic neuroendocrine tumors (pNETs) account for 1%–2% of pancreatic tumors, with an increasing incidence. The safety of concurrent pancreas‐liver resections remains uncertain. This study evaluated the national outcomes of concurrent pancreatectomy and liver‐directed surgery for pNETs. Methods ACS‐NSQIP (2019–2023)
Amir Ebadinejad +4 more
wiley +1 more source
Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig
, 1999 5-Amino-4-imidazolecarboxamide riboside (AICAr) or acadesine has been proposed to exert cardioprotection by enhancing adenosine production in ischemic myocardium.
Mohinder PS Randhawa, Jr. +3 more
core +1 more source
Journal of Surgical Oncology, EarlyView.ABSTRACT Introduction Advances in neoadjuvant therapy and surgical techniques have led to more total pancreatectomies (TP) with vascular resection for pancreatic cancer. This study assesses contemporary outcomes of TP with venous (VR) and arterial (AR) resections compared to non‐vascular resection (NVR).
Zofia Czarnecka +3 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Aspartyl‐tRNA synthetase 2 (DARS2), the mitochondrial enzyme responsible for aminoacylation of aspartyl‐tRNA, is traditionally known for its effect on protein synthesis. Recently, DARS2 is reported to be implicated in tumorigenesis. However, its specific effect on breast cancer (BC) is poorly understood.
Na Wang, Ming Huang
wiley +1 more source
Intracellular calcium dynamics in mouse model of myocardial stunning
, 1998 Intracellular calcium ([Formula: see text]) and left ventricular (LV) function were determined in the coronary-perfused mouse heart to study[Formula: see text]-related mechanisms of injury from myocardial ischemia and reperfusion.
Ivo Amende +3 more
core +1 more source