Results 121 to 130 of about 337,957 (243)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

open access: yesSmart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang   +8 more
wiley   +1 more source

Table2_Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats.docx

open access: yes
Background and aimsIschemic preconditioning (IPC), i.e., brief periods of ischemia, protect the heart from subsequent prolonged ischemic injury, and reduces infarction size. Myocardial stunning refers to transient loss of contractility in the heart after
Erik Axel Andersson (18158083)   +16 more
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

open access: yesVIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika   +6 more
wiley   +1 more source

A stunning experience

open access: yes, 2014
‘A Stunning Experience’ pits Oprah Winfrey and David Letterman against each other in an infinite interview. Through simple editing and compositing, both parties are rendered mute, positioned at either edge of a black void.
McKewen, Daniel
core  

Ischaemic Optic Neuropathy After Cardiac Surgery: A Systematic Review and Meta‐Analysis of Incidence and Risk Factors

open access: yesANZ Journal of Surgery, EarlyView.
Across 11 observational studies comprising 6 471 577 patients, the pooled incidence of ischaemic optic neuropathy after cardiac surgery was approximately 1.5 cases per 10 000 procedures. Coronary artery disease, peripheral vascular disease and anaemia were associated with increased odds of ION, although these findings should be interpreted in the ...
Daud Mutahar   +11 more
wiley   +1 more source

Contrast echocardiography in the diagnosis of myocardial stunning

open access: yes, 1999
The identification of viable myocardium within dysfunctional myocardium has important clinical implications. By using a microvascular tracer, myocardial contrast echocardiography may have the potential for prediction of myocardial viability in the acute ...
Rovai D   +6 more
core  

Table3_Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats.docx

open access: yes
Background and aimsIschemic preconditioning (IPC), i.e., brief periods of ischemia, protect the heart from subsequent prolonged ischemic injury, and reduces infarction size. Myocardial stunning refers to transient loss of contractility in the heart after
Erik Axel Andersson (18158083)   +16 more
core   +1 more source

Delivery mode and maternal health conditions before and after childbirth: A population‐based cohort study from Estonia

open access: yesActa Obstetricia et Gynecologica Scandinavica, EarlyView.
Cesarean section is associated with higher rates of chronic health conditions and pregnancy‐related complications, whereas vaginal delivery is more commonly linked to pelvic floor and perineal complications. These findings emphasize the need for individualized decision‐making and thorough counseling about the risks and benefits of each delivery method.
Katrin Täär   +13 more
wiley   +1 more source

National Practice Patterns of VA ECMO and Left Ventricular Mechanical Unloading for Cardiogenic Shock

open access: yesArtificial Organs, EarlyView.
Consensus surrounding the management of VA ECMO and left ventricular mechanical unloading for cardiogenic shock (CS) is limited. We thus conducted a national survey of practice patterns in the treatment of CS to characterize such variability, finding large heterogeneity in CS diagnosis, VA ECMO initiation, and LVMU strategies.
Dustin M. Anderson‐Bell   +16 more
wiley   +1 more source

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