Results 171 to 180 of about 130,790 (247)

Clonal hematopoiesis in patients with cancer and cancer survivors: From clonal burden to cardiovascular diseases

Cancer, Volume 132, Issue 10, 15 May 2026.
ABSTRACT Over the past decade, clonal hematopoiesis (CH) has gained substantial attention as a prevalent, age‐associated phenomenon with major implications for hematologic malignancy, cardiovascular disease, and mortality. CH arises from the clonal expansion of hematopoietic stem cells and progenitor cells harboring somatic mutations, most commonly in ...
Christian H. Nenninger, Keith Anderson, Jenaro Espitia‐Corredor, Brittany Echevarria, Vertica Agnihotri, Zhao Wang, Scott R. Goldsmith, June‐Wha Rhee   +7 more
wiley   +1 more source

Critical Reappraisal of Takotsubo Syndrome (TS) and Myocarditis Association: "The Myocarditis-Like Features" Seen in TS Are Secondary Changes and not True Myocarditis. [PDF]

Rev Cardiovasc Med
Y-Hassan S.
europepmc   +1 more source

The ERβ Agonist, OSU‐ERβ‐012, Mitigates Inflammation in a Chimeric Model of Systemic Lupus Erythematosus

ACR Open Rheumatology, Volume 8, Issue 5, May 2026.
Objective Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ damage, affecting women between the ages of 15 and 45 years at a 9:1 rate as compared to men. The etiology of SLE is complex and elusive; however, the susceptibility of women during the years in which estrogen levels are at their highest suggests a ...
Braden Zeno, Shane Bruckner, Hongyu Yuan, Morgan Stahl, Timothy Alexandrov, Kyle Jablonski, Judith Lin, Nicholas A. Young, Wael N. Jarjour   +8 more
wiley   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Immune checkpoint inhibitor-related myocarditis in patients with thymic epithelial tumors: a retrospective cohort analysis. [PDF]

Cancer Immunol Immunother
Zeng H, Kang J, Pu S, Dai C, Jiang J, Chen Y, Chen Y, Fu L, Liu H, Guo M, Yi H, Chen H, Zhong W, Xue Y.   +13 more
europepmc   +1 more source

Integration Analysis of Bayesian and Machine Learning for Heterogeneity, Biomarkers, and Optimal Combination Regimens of Pucotenlimab in Solid Tumors

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT The efficacy of PD‐1 inhibitor pucotenlimab (HX008) in solid tumors exhibits heterogeneity. This study integrated data from 6 clinical trials (covering gastric/gastroesophageal junction cancer, triple‐negative breast cancer, melanoma, and dMMR/MSI‐H solid tumors) using Bayesian meta‐analysis, machine learning (optimal XGBoost AUC = 0.86), and ...
Yingge He, Changqing Gao, Shiyan Zhang, Yonghui Hao, Shuning He, Ke Peng, Liqi Li   +6 more
wiley   +1 more source

Evidence for Autoimmunity in the Pathogenesis of COVID-19-Induced Myocarditis. [PDF]

Int J Mol Sci
Tuvali O, Welt M, Benaim C, Fassler M, George J.   +4 more
europepmc   +1 more source

Most costly and prevalent reasons for hospitalization in children with medical complexity in Ontario, Canada

Journal of Hospital Medicine, Volume 21, Issue 5, Page 495-505, May 2026.
Abstract Background and Objectives Children with medical complexity (CMC) have chronic health conditions often associated with functional limitations. CMC comprise 1%–5% of the pediatric population. In Canada, their care accounts for one‐third of pediatric health spending.
Erin Hessey, Thaksha Thavam, Sanjay Mahant, Eyal Cohen, Jingqin Zhu, Francine Buchanan, Teresa To, Peter J. Gill, Ontario Pediatric Hospital Care Study Group (OPHCSG) and the Canadian Paediatric Inpatient Research Network (PIRN), Wenjia Chen, Ronald Cohn, Mairead Green, Matt Hall, Kate Langrish, Colin Macarthur, Myla Moretti, Patricia Parkin, Michelle Quinlan, Ann Bayliss, Ronik Kanani, Sean Murray, Catherine Pound, Mahmoud Sakran, Anupam Sehgal, Sepi Taheri, Gita Wahi   +25 more
wiley   +1 more source

Clinical Features and Associated Factors of Lupus Myocarditis: A Case-Control Study. [PDF]

Immun Inflamm Dis
Yan D, Li S, Yan M, Liu Z, Xue L.
europepmc   +1 more source

Suppression of Calcium Influx Reduces Coxsackievirus B3 Lethality With Elevated Interferon Beta Responses in Mice

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT The disease course of severe enterovirus (EV) infection with hepatic necrosis is usually fulminant and fatal. Coxsackievirus (CVB3) is the emerging and important serotype of newborn EV inducing hepatic necrosis. Calcium (Ca2+) regulates host immunity, type I interferon (IFN‐I), and viral infections.
Yi‐Ling Hsiao, Cheng‐Huei Hung, Ming Te Yeh, Shun‐Hua Chen   +3 more
wiley   +1 more source