Results 51 to 60 of about 57,090 (240)

Clinical utility of cardiac troponin measurement in COVID-19 infection [PDF]

, 2020
The novel coronavirus SARS-CoV-2 causes the disease COVID-19, a severe acute respiratory syndrome. COVID-19 is now a global pandemic and public health emergency due to rapid human-to-human transmission.
Gaze, D.C., Gaze, D.C.
core   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Biopsy-proven myocarditis: peripheral immunophenotypes correlate with histology, etiology, immunosuppressive therapy

Journal of Translational Autoimmunity
Background: Myocarditis is an inflammatory disease of the myocardium with infectious or immune-mediated/autoimmune etiology; etiology diagnosis relays on endomyocardial biopsy (EMB).
Cristina Vicenzetto, Andrea Silvio Giordani, Anna Baritussio, Federico Scognamiglio, Maria Grazia Peloso-Cattini, Elena Pontara, Elisa Bison, Gloria Brigiari, Giuseppe Tarantini, Massimo Napodano, Giuseppe Toscano, Dario Gregori, Elisa Carturan, Monica De Gaspari, Stefania Rizzo, Cristina Basso, Renzo Marcolongo, Alida Linda Patrizia Caforio   +17 more
doaj   +1 more source

Mortality associated with avian reovirus infection in a free-living magpie (Pica pica) in Great Britain [PDF]

, 2015
Avian reoviruses (ARVs) cause a range of disease presentations in domestic, captive and free-living bird species. ARVs have been reported as a cause of significant disease and mortality in free-living corvid species in North America and continental ...
Cunningham, AA, Dastjerdi, A, Everest, D, Hicks, D, Horton, DL, Irvine, RM, Lawson, B, Núñez, A, Pocknell, A, Shah, S   +9 more
core   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Reviewing the current diagnostic and treatment approaches for myocarditis – analysis of literature

Quality in Sport
Introduction: Myocarditis is an inflammatory disease of the heart muscle, presenting with symptoms ranging from mild discomfort to severe cardiac dysfunction.
Damian Zys, Maciej Wojszczyk, Julia Ryniecka, Witold Czyż, Julia Kacperczyk, Marta Chuncia-Ileczko, Michalina Wójcikiewicz, Filip Arczewski, Karol Dziedzic, Julia Kulbacka   +9 more
doaj   +1 more source

Myocarditis and inflammatory cardiomyopathy: from diagnosis to treatment

Türk Kardiyoloji Derneği Arşivi, 2015
Based on the definition in the European Society of Cardiology statement, myocarditis is an inflammatory disease of the myocardium diagnosed by established histological, immunological, and immunohistochemical criteria, whereas inflammatory cardiomyopathy ...
Felicitas Escher, Carsten Tschoepe, Dirk Lassner, Heinz-Peter Schultheiss   +3 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Neonatal Myocardial Infarction or Myocarditis? [PDF]

, 2011
We report a 29 week-gestation preterm infant who presented during his second week of life with cardiogenic shock. Clinical presentation and first diagnostics suggested myocardial infarction, but echocardiographic features during follow-up pointed to a ...
A Arthur, A Tillett, AJ Tometzki, Albertus Timmer, Beatrijs Bartelds, C Berry, D Bernstein, D Garel, D Inwald, DM Saker, DW Sapire, GE Burch, H Kilbride, IM Baldew, J Boulton, J Hruda, JM Morgan, Joost P. van Melle, KL Baughman, Klasien A. Bergman, L Abdurrahman, LA Iannone, Leanne de Vetten, LF Fagan, LG Hauwert Van der, M Fletcher, M Nathan, M Schryer, M Takeuchi, MH Gault, MZ Akkad, ND Reich, Nynke J. Elzenga, PF Lehoullier, S Ferns, S Sandhyamani, SJ Murugan, TS Hornung, VW Lucas Jr, WL Hu   +39 more
core   +2 more sources

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source