Results 51 to 60 of about 109,922 (297)

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Biopsy-proven myocarditis: peripheral immunophenotypes correlate with histology, etiology, immunosuppressive therapy

Journal of Translational Autoimmunity
Background: Myocarditis is an inflammatory disease of the myocardium with infectious or immune-mediated/autoimmune etiology; etiology diagnosis relays on endomyocardial biopsy (EMB).
Cristina Vicenzetto, Andrea Silvio Giordani, Anna Baritussio, Federico Scognamiglio, Maria Grazia Peloso-Cattini, Elena Pontara, Elisa Bison, Gloria Brigiari, Giuseppe Tarantini, Massimo Napodano, Giuseppe Toscano, Dario Gregori, Elisa Carturan, Monica De Gaspari, Stefania Rizzo, Cristina Basso, Renzo Marcolongo, Alida Linda Patrizia Caforio   +17 more
doaj   +1 more source

A systematic review of myasthenia gravis complicated with myocarditis

Brain and Behavior, 2021
Among many of the autoimmune diseases observed in patients with myasthenia gravis (MG), myocarditis is one of the most critical. The goal of this review is to systematically describe and investigate the characteristics of MG complicated with myocarditis.
Wei Cheng, Tian Sun, Cong Liu, Zijing Zhou, Jiaxi Duan, Yiyang Zhao, Min Yang, Ping Chen   +7 more
doaj   +1 more source

Viral Myocarditis: Classification, Diagnosis, and Clinical Implications

Frontiers in Cardiovascular Medicine, 2022
Myocarditis is an inflammatory disease of the myocardium with focal or diffuse involvement. Viral infections are the most common cause of myocarditis, especially in Western countries.
Fabiola B. Sozzi, Elisa Gherbesi, Andrea Faggiano, Eleonora Gnan, Alessio Maruccio, Marco Schiavone, Laura Iacuzio, Stefano Carugo   +7 more
doaj   +1 more source

Expert Perspectives: Toward Treat‐to‐Target Management in Adult Idiopathic Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Treat‐to‐target has transformed the management of several rheumatic diseases through predefined therapeutic goals, structured disease assessment, and timely treatment adjustment. Despite major advances in the understanding and treatment of idiopathic inflammatory myopathies (IIM), a formal treat‐to‐target framework for adult IIM has not yet been ...
Shiri Keret, Nantakarn Pongtarakulpanit, Rohit Aggarwal   +2 more
wiley   +1 more source

Multiparametric Cardiac Magnetic Resonance Imaging to Discriminate Endomyocardial Biopsy-Proven Chronic Myocarditis From Healed Myocarditis. [PDF]

BACKGROUND Detecting ongoing inflammation in myocarditis patients has prognostic relevance, but there are limited data on the detection of chronic myocarditis and its differentiation from healed myocarditis.
Brendel, Jan M, Hagen, Florian, Blankstein, Ron, Krumm, Patrick, Kübler, Jens, Greulich, Simon, Nikolaou, Konstantin, Gräni, Christoph, Klingel, Karin, Gawaz, Meinrad, Brendel, Jan Michael, Gawaz, Meinrad Paul   +11 more
core   +2 more sources

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

COVID-19 vaccine-associated myocarditis: Analysis of the suspected cases reported to the EudraVigilance and a systematic review of the published literature

International Journal of Cardiology: Heart & Vasculature, 2023
Background: Myocarditis secondary to Coronavirus Disease 2019 (COVID-19) vaccination has been reported in the literature. Objective: This study aimed to characterize the reported cases of myocarditis after COVID-19 vaccination based on age, gender, doses,
Vikash Jaiswal, Dattatreya Mukherjee, Song Peng Ang, Tejasvi Kainth, Sidra Naz, Abhigan Babu Shrestha, Vibhor Agrawal, Saloni Mitra, Jia Ee Chia, Bernd Jilma, Mamas A. Mamas, Catherine Gebhard, Marek Postula, Jolanta M. Siller-Matula   +13 more
doaj   +1 more source

In silico analysis of putative interactions identifies fibroblasts as hubs for cell–cell communication during early regeneration of the zebrafish heart

Developmental Dynamics, EarlyView.
Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho, Prateek Arora, Ines J. Marques, María Galardi‐Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader   +6 more
wiley   +1 more source