Results 81 to 90 of about 177,501 (382)

Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor–Induced Myocarditis

Circulation, 2022
Background: Immune checkpoint inhibitors (ICIs) are monoclonal antibodies used to activate the immune system against tumor cells. Despite therapeutic benefits, ICIs have the potential to cause immune-related adverse events such as myocarditis, a rare but
Han Zhu, Francisco X. Galdos, Daniel Lee, Sarah Waliany, Y. Huang, J. Ryan, Katherine Dang, J. Neal, H. Wakelee, S. Reddy, S. Srinivas, Lih-Ling Lin, R. Witteles, H. Maecker, Mark M. Davis, P. Nguyen, Sean M. Wu   +16 more
semanticscholar   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Reviewing the current diagnostic and treatment approaches for myocarditis – analysis of literature

Quality in Sport
Introduction: Myocarditis is an inflammatory disease of the heart muscle, presenting with symptoms ranging from mild discomfort to severe cardiac dysfunction.
Damian Zys, Maciej Wojszczyk, Julia Ryniecka, Witold Czyż, Julia Kacperczyk, Marta Chuncia-Ileczko, Michalina Wójcikiewicz, Filip Arczewski, Karol Dziedzic, Julia Kulbacka   +9 more
doaj   +1 more source

COVID-19 Vaccines and Myocarditis: An Overview of Current Evidence

Biomedicines, 2023
COVID-19 vaccines have been widely used to reduce the incidence and disease severity of COVID-19. Questions have lately been raised about the possibility of an association between COVID-19 vaccines and myocarditis, an inflammatory condition affecting the
Altijana Hromić-Jahjefendić, Abas Sezer, Alaa A. A. Aljabali, Ángel Serrano-Aroca, Murtaza M. Tambuwala, Vladimir N. Uversky, Elrashdy M. Redwan, Debmalya Barh, Kenneth Lundstrom   +8 more
doaj   +1 more source

Mycoplasma pneumonia : an unusual cause of acute myocarditis in childhood [PDF]

, 2006
Mycoplasma pneumoniae is primarily a respiratory pathogen but may affect exhibit a diverse range of presentations from asymptomatic infection to life threatening conditions. Myocarditis of varying severity is an unusual complication.
Bailey, Mark, Barbara, Christopher, Formosa Gouder, Mireille, Grech, Victor E., Muscat, C.   +4 more
core  

COVID-19 and myocarditis: a systematic review and overview of current challenges

Heart Failure Reviews, 2021
Myocardial inflammation in COVID-19 has been documented. Its pathogenesis is not fully elucidated, but the two main theories foresee a direct role of ACE2 receptor and a hyperimmune response, which may also lead to isolated presentation of COVID-19 ...
T. Castiello, G. Georgiopoulos, G. Finocchiaro, M. Claudia, A. Gianatti, D. Delialis, Alberto Aimo, S. Prasad   +7 more
semanticscholar   +1 more source

Disruption of the blood–brain barrier contributes to neurobehavioral changes observed in rheumatic heart disease

Animal Models and Experimental Medicine, EarlyView.
Sydenham's chorea (SC) is the neurological manifestation associated with acute rheumatic fever (ARF), triggered by a group A streptococcal (GAS) infection. Anti‐GAS antibodies cross‐reacting with tissue proteins are implicated in the development of neurological changes. In this study, using an animal model, we demonstrate that a compromised blood–brain
Rukshan Ahamed Mohamed Rafeek, Riya Thapa, Samarjeet Saluja, Bipandeep Banga, David McMillan, Kadaba Sri Sriprakash, Nicholas M. Andronicos, Adam Hamlin, Natkunam Ketheesan   +8 more
wiley   +1 more source

IMMUNOLOGICAL FEATURES OF INFLAMMATORY MYOCARDIAL DISEASES DUE TO VIRAL INFECTIONS

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Autoantibodies to myocardial antigenic epitopes and corresponding autoreactive T cell clones play an important role in myocardial damage and in pathogenesis of infectious immune myocarditis.
F. N. Paleev, N. P. Sanina, A. I. Makarkov, N. M. Mylov, E. I. Ostrovskiy, N. N. Khishova, O. V. Moskalets, N. R. Paleev   +7 more
doaj   +1 more source

Cats with thermal burn injuries from California wildfires show echocardiographic evidence of myocardial thickening and intracardiac thrombi. [PDF]

, 2020
Recent increases in the prevalence and severity of wildfires in some regions have resulted in an increased frequency of veterinary burn patients. Few studies exist regarding diagnostics and management of burn wounds in veterinary patients and current ...
Epstein, Steven E, Gunther-Harrington, Catherine T, Li, Ronald HL, Sharpe, Ashley N, Stern, Joshua A   +4 more
core  

Gap junction reduction in cardiomyocytes following transforming growth factor- beta treatment and Trypanosoma cruzi infection [PDF]

, 2009
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta).
Becker, D, Burnstock, G, Coutinho-Silva, R, de Araujo-Jorge, TC, Feige, JJ, Higuchi, MD, Waghabi, MC   +6 more
core   +2 more sources