Results 41 to 50 of about 342,256 (353)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Automatic feature extraction algorithms for the assessment of in-vitro electrical recordings of rat myocardium with ablation lesions

Current Directions in Biomedical Engineering, 2017
Cardiac arrhythmias are a widely spread disease in industrialized countries. A common clinical treatment for this disease is radiofrequency ablation (RFA), in which high frequency alternating current creates a lesion on the myocardium.
Gross Carl, Pollnow Stefan, Dössel Olaf, Lenis Gustavo   +3 more
doaj   +1 more source

Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundNitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide.
Toru Hashimoto, Vidhya Sivakumaran, Ricardo Carnicer, Guangshuo Zhu, Virginia S. Hahn, Djahida Bedja, Alice Recalde, Drew Duglan, Keith M. Channon, Barbara Casadei, David A. Kass   +10 more
doaj   +1 more source

Cardio-sarcopenia: A syndrome of concern in aging

Frontiers in Medicine, 2022
Cardiac alterations in structure and function, namely, the left ventricle, have been intensely studied for decades, in association with aging. In recent times, there has been keen interest in describing myocardial changes that accompany skeletal muscle ...
De Rong Loh, Ru-San Tan, Ru-San Tan, Wee Shiong Lim, Wee Shiong Lim, Angela S. Koh, Angela S. Koh   +6 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Layer‐specific myocardial function in asymptomatic cats with obstructive hypertrophic cardiomyopathy assessed using 2‐dimensional speckle‐tracking echocardiography

Journal of Veterinary Internal Medicine, 2019
Background Hypertrophic cardiomyopathy (HCM), a primary disorder of the myocardium, is the most common cardiac disease in cats. However, determination of layer‐specific myocardial function with 2D speckle‐tracking echocardiography in cats with ...
Ryohei Suzuki, Yohei Mochizuki, Hiroki Yoshimatsu, Ayaka Niina, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama   +6 more
doaj   +1 more source

The effect of L-arginine and L-NAME on myocardial capillary density in normal rats

Advanced Biomedical Research, 2013
Background: This study evaluated the effect of L-arginine (Nitric Oxide (NO) precursor) and L-NG-Nitroarginine Methyl Ester (L-NAME) (NO synthase inhibitor) on myocardial capillary density in normal rats.
Majid Khazaei, Muhammad Amin Moshayedi, Massoud Teimouri Jervekani, Shahrzad Aghili, Saeed Montazer, Roshanak Mehdipour Dastjerdi, Fazlolah Hashemzehi, Hourossadat Hashemi Jazi   +7 more
doaj   +1 more source

Simultaneous muscle force and displacement transducer [PDF]

, 1980
A myocardial transducer for simultaneously measuring force and displacement within a very small area of myocardium is disclosed. The transducer comprised of an elongated body forked at one end to form an inverted Y shaped beam with each branch of the ...
Culler, V. H., Feldstein, C., Lewis, G. W.   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. [PDF]

, 2018
RationaleMutations in the transcription factor TBX20 (T-box 20) are associated with congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development and embryonic lethality by embryonic day 9.5.
Aneas, Ivy, Bogomolovas, Julius, Boogerd, Cornelis J, Chen, Ju, Evans, Sylvia M, Joslin, Amelia C, Montefiori, Lindsey, Nobrega, Marcelo A, Sakabe, Noboru, Sobreira, Debora R, Zhang, Lunfeng, Zhou, Bin, Zhu, Xiaoming   +12 more
core   +2 more sources