Results 21 to 30 of about 177,871 (261)

Morphological changes in the heart and aorta of rats with diet-induced metabolic syndrome

Бюллетень сибирской медицины, 2022
Aim. To identify early morphological changes in the heart and aorta of rats with experimental metabolic syndrome induced by a high-fat and high-carbohydrate diet (HFHCD).Materials and methods. The study was carried out on male Wistar rats.
J. G. Birulina, V. V. Ivanov, E. E. Buyko, V. V. Bykov, A. N. Dzyuman, А. V. Nosarev, A. V. Grigoreva, S. V. Gusakova   +7 more
doaj   +1 more source

Research progress of exercise training in rehabilitation of patients with chronic heart failure (慢性心力衰竭患者运动康复研究进展)

中西医结合护理, 2023
Exercise training is effective to improve the quality of life and physical function of patients with chronic heart failure. This paper reviewed the studies on exercise training in rehabilitation of patients with chronic heart failure, in order to provide
SONG Yawen (宋雅文), ZHOU Lin (周林), WU Mengmeng (武蒙蒙), DU Haixia (杜海霞), WU Qingyun (吴青云)   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Mesoscopic anatomy and histotopography of the left atrial appendage walls in human fetal heart

Сибирский научный медицинский журнал
Normal anatomy of the left atrial appendage (LAA) of human fetus is of a great importance for fetal cardiac surgery and heart bioprinting. Aim of the study was to clarify the mesoscopic anatomy and histotopography of different parts of the LAA walls in ...
A. A. Gaponov, I. D. Ufimtseva, E. G. Dmitrieva, D. K. Kuznetsov, V. I. Pryakhina, A. A. Iakimov   +5 more
doaj   +1 more source

Automatic feature extraction algorithms for the assessment of in-vitro electrical recordings of rat myocardium with ablation lesions

Current Directions in Biomedical Engineering, 2017
Cardiac arrhythmias are a widely spread disease in industrialized countries. A common clinical treatment for this disease is radiofrequency ablation (RFA), in which high frequency alternating current creates a lesion on the myocardium.
Gross Carl, Pollnow Stefan, Dössel Olaf, Lenis Gustavo   +3 more
doaj   +1 more source

Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundNitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide.
Toru Hashimoto, Vidhya Sivakumaran, Ricardo Carnicer, Guangshuo Zhu, Virginia S. Hahn, Djahida Bedja, Alice Recalde, Drew Duglan, Keith M. Channon, Barbara Casadei, David A. Kass   +10 more
doaj   +1 more source

Cardio-sarcopenia: A syndrome of concern in aging

Frontiers in Medicine, 2022
Cardiac alterations in structure and function, namely, the left ventricle, have been intensely studied for decades, in association with aging. In recent times, there has been keen interest in describing myocardial changes that accompany skeletal muscle ...
De Rong Loh, Ru-San Tan, Ru-San Tan, Wee Shiong Lim, Wee Shiong Lim, Angela S. Koh, Angela S. Koh   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Layer‐specific myocardial function in asymptomatic cats with obstructive hypertrophic cardiomyopathy assessed using 2‐dimensional speckle‐tracking echocardiography

Journal of Veterinary Internal Medicine, 2019
Background Hypertrophic cardiomyopathy (HCM), a primary disorder of the myocardium, is the most common cardiac disease in cats. However, determination of layer‐specific myocardial function with 2D speckle‐tracking echocardiography in cats with ...
Ryohei Suzuki, Yohei Mochizuki, Hiroki Yoshimatsu, Ayaka Niina, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama   +6 more
doaj   +1 more source

The effect of L-arginine and L-NAME on myocardial capillary density in normal rats

Advanced Biomedical Research, 2013
Background: This study evaluated the effect of L-arginine (Nitric Oxide (NO) precursor) and L-NG-Nitroarginine Methyl Ester (L-NAME) (NO synthase inhibitor) on myocardial capillary density in normal rats.
Majid Khazaei, Muhammad Amin Moshayedi, Massoud Teimouri Jervekani, Shahrzad Aghili, Saeed Montazer, Roshanak Mehdipour Dastjerdi, Fazlolah Hashemzehi, Hourossadat Hashemi Jazi   +7 more
doaj   +1 more source