Results 101 to 110 of about 72,492 (253)

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling

ESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.
Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely, Tamás Kovács, Andrea Kovács, Viktória E. Tóth, Nabil V. Sayour, Gábor M. Mórotz, Csenger Kovácsházi, Gábor B. Brenner, Zsófia Onódi, Balázs Enyedi, Domokos Máthé, Przemyslaw Leszek, Zoltán Giricz, Péter Ferdinandy, Zoltán V. Varga   +14 more
wiley   +1 more source

Investigation of the Role of Myocyte Orientations in Cardiac Arrhythmia Using Image-Based Models

, 2019
Cardiac electrical excitation-propagation is influenced by myocyte orientations (cellular organization). Quantitatively understanding this relationship presents a significant research challenge, especially during arrhythmias in which excitation patterns ...
Colman, MA, Schneider, JE, Benson, AP, Teh, I, Whittaker, DG   +4 more
core   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Pulsed wave tissue Doppler imaging of the left ventricle in foals: Feasibility, inter‐ and intra‐observer variability and wave pattern over the first days of life

Equine Veterinary Journal, EarlyView.
Abstract Background Tissue Doppler imaging (TDI) may improve the assessment of myocardial function in neonatal foals. Objectives To document the feasibility of left ventricular pulsed wave (PW) TDI, inter‐ and intra‐observer variability and wave pattern over the first 5 days of life. Study Design Prospective observational study.
Fernanda Timbó D'el Rey Dantas, Gayle Hallowell, Carolina Castagnetti, Giovanni Romito, Laura Menchetti, Aurora Mannini, Aliai Lanci, Jole Mariella, Francesca Freccero   +8 more
wiley   +1 more source

Myocyte Turnover in the Aging Human Heart

, 2010
Rationale: The turnover of cardiomyocytes in the aging female and male heart is currently unknown, emphasizing the need to define human myocardial biology.
Beltrami C.A., Clavo Rondon C., BELTRAMI, Carlo Alberto, CLAVO RONDON C, Beltrami AP, Kajstura J., DEL MONTE F, BUCHHOLZ BA, BELTRAMI, Antonio Paolo, Beltrami A.P., GURUSAMY N, Beltrami CA, Hosoda T., Gurusamy N., BARDELLI S, Cesselli D, Anversa P, CESSELLI, Daniela, D'AMARIO D, HOSODA T, QUAINI F, Ogórek B., D'Amario D., Buchholz B.A., Rota M., OGÓREK B, Goichberg P., KAJSTURA J, LERI A, GOICHBERG P, BUSSANI R, Leri A., ANVERSA P., Cesselli D., BUSSANI, ROSSANA, Quaini F., ROTA M, Clavo-Rondon C, Bardelli S., del Monte F.   +39 more
core   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

A Broad-Spectrum Chemokine Inhibitor Drives M2 Macrophage Polarization Through Modulation of the Myometrial Secretome

Cells
The uterine smooth muscle (myometrium) is an immunomodulatory tissue capable of secreting multiple chemokines during pregnancy. We propose that before term labor, chemokines secreted as a result of mechanical stretch of the uterine walls by the growing ...
Adam Boros-Rausch, Anna Dorogin, Lubna Nadeem, Oksana Shynlova, Stephen James Lye   +4 more
doaj   +1 more source

CARDIAC MYOCYTE NECROSIS INDUCED BY ANGIOTENSIN-II

, 1991
Although the role of angiotensin II (Ang II) in the pathogenesis and progression of the failing heart is uncertain, previous reports have suggested that myocyte injury may be a component in this process. In this study, we investigated this possibility in
JALIL, JE, PICK, R, WEBER, KT, JANICKI, JS, TAN, LB   +4 more
core   +1 more source