Results 291 to 300 of about 124,243 (355)

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source

Cardiomyocyte Nuclear Pleomorphism in a Mouse Model of Inherited Hypertrophic Cardiomyopathy. [PDF]

J Cardiovasc Dev Dis
Johnston JR, Leite Coscarella I, Rose CL, Shi Y, Rastegarpouyani H, Jones KMD, Le Patourel JM, Ogunfuwa F, Martins AS, Crotty KM, Ward Molla KM, Reinoso TR, Waldmann TL, Irianto J, Wang YJ, Wang L, Knollmann BC, Pinto JR, Chase PB.   +18 more
europepmc   +1 more source

Insights from electromechanical simulations to assess omecamtiv mecarbil efficacy in heart failure

The Journal of Physiology, EarlyView.
Abstract figure legend Impact of Omecamtiv Mecarbil (OM) on in‐silico models of heart failure. A mathematical electromechanical model of human ventricular tissue is used to simulate the effects of OM in heart failure with reduced ejection fraction (HFrEF).
Maria Teresa Mora, Ilse van Herck, Cécile Daversin‐Catty, Henrik Finsberg, Jordi Llopis‐Lorente, Javier Saiz, Hermenegild Arevalo, Samuel Wall, Beatriz Trenor   +8 more
wiley   +1 more source

Metabolite‐sensitive cross‐bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we used mathematical modelling to explore the effect of diabetes on muscle mechanoenergetics. Our parameterisation of cross‐bridge models using data from non‐diabetic and diabetic human atrial tissues revealed lower values for cross‐bridge stiffness, detachment rates, attachment rates and lower ATP sensitivity in ...
Julia H. Musgrave, June‐Chiew Han, Marie‐Louise Ward, Andrew J. Taberner, Kenneth Tran   +4 more
wiley   +1 more source

Dynamic Expression and Functional Implications of the Cell Polarity Gene, Dchs1, During Cardiac Development. [PDF]

Cells
Byerly K, Wolfe C, Parris H, Griggs C, Wilson E, Huff M, Griggs M, Morningstar J, Guo L, Tang F, Guz J, Petrucci T, Phookan R, Loizzi B, Gensemer C, Norris RA.   +15 more
europepmc   +1 more source

Mapping intellectual structure and research hotspots in the field of coronary heart disease and apoptosis: A bibliometric analysis from 1994 to 2025. [PDF]

Medicine (Baltimore)
Jin W, Yu Q, Wang S.
europepmc   +1 more source

Transcription factor MITF regulates masseter muscle growth and development. [PDF]

Physiol Rep
Nariyama M, Ohnuki Y, Suita K, Ishikawa M, Matsubara R, Matsuo I, Mitsubayashi T, Mototani Y, Ito A, Abe M, Hayakawa Y, Nomura T, Wada S, Asada Y, Okumura S.   +14 more
europepmc   +1 more source

Combined inhibition of atrial‐specific potassium currents as a possible anti‐arrhythmic drug therapy: A match made in silico

The Journal of Physiology, EarlyView.
Vladimír Sobota
wiley   +1 more source