Results 311 to 320 of about 124,243 (355)
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Myocyte renewal and ventricular remodelling
Nature, 2002Remaining young at heart is a desirable but elusive goal. Unbeknown to us, however, myocyte regeneration may accomplish just that. Continuous cell renewal in the adult myocardium was thought to be impossible, but multipotent cardiac stem cells may be able to renew the myocardium and, under certain circumstances, can be coaxed to repair the broken heart
Piero, Anversa, Bernardo, Nadal-Ginard
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Microtubules in Cardiac Myocytes
1988Publisher Summary This chapter describes the distribution of microtubules (MTs) in various physiopathological states and of their involvement in a broad spectrum of cellular processes. MTs, like actin filaments, are made up of globular protein subunits that can assemble and disassemble rapidly in the cell.
L, Rappaport, J L, Samuel
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Myocyte Growth and Cardiac Repair
Journal of Molecular and Cellular Cardiology, 2002Introduced several decades ago, the dogma persists that ventricular myocytes are terminally differentiated cells and cardiac repair by myocyte regeneration is completely inhibited shortly after birth. On the basis that cardiac myocytes are unable to divide in the adult heart, myocyte growth under physiologic and pathologic conditions is believed to be ...
Piero, Anversa +3 more
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Myocytes, Myometrium, and Uterine Contractions
Annals of the New York Academy of Sciences, 2006Abstract: The pregnant uterus is unique because of the dramatic functional changes that occur in the peripartum period. To promote the concept that we have a relatively poor understanding of the physiology of parturition, we will posit 10 facts that are so obvious and so clearly accepted as facts that they probably are not even facts at all.
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Myocyte aging and mitochondrial turnover
Experimental Gerontology, 2004Cardiac myocytes, skeletal muscle fibers, and other long-lived postmitotic cells show dramatic age-related alterations that mainly affect mitochondria and the lysosomal compartment. Mitochondria are primary sites of reactive oxygen species formation that causes progressive damage to mitochondrial DNA and proteins in parallel to intralysosomal ...
Alexei, Terman, Ulf T, Brunk
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Nihon rinsho. Japanese journal of clinical medicine, 2003
In contrast to conventional assumption that myocytes are never renewed after birth, a growing body of evidence suggests that human cardiac myocytes might divide in myocardial infarction and severe heart failure. Bone marrow cells may also contribute to myocyte regeneration, when injected or mobilized into systemic circulation by cytokines.
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In contrast to conventional assumption that myocytes are never renewed after birth, a growing body of evidence suggests that human cardiac myocytes might divide in myocardial infarction and severe heart failure. Bone marrow cells may also contribute to myocyte regeneration, when injected or mobilized into systemic circulation by cytokines.
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Myocyte Changes in Heart Failure
Heart Failure Clinics, 2012Structural remodeling is a major feature of heart failure and typically precedes the development of symptomatic disease. Structural remodeling of the heart reflects changes in myocyte morphology. Disproportional myocyte growth is observed in pathologic concentric hypertrophy (myocyte thickening) and in eccentric dilated hypertrophy (myocyte lengthening)
Olga V, Savinova, A Martin, Gerdes
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1989
Abstract : The crucial events leading to loss of cell viability after hypoxic and toxic injury remain poorly understood. Cell death is rarely synchronous, and rapidly occurring events leading to irreversible injury may be obscured when large cell populations are studied. To overcome this drawback, single cultured hepatocytes and myocytes during hypoxic
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Abstract : The crucial events leading to loss of cell viability after hypoxic and toxic injury remain poorly understood. Cell death is rarely synchronous, and rapidly occurring events leading to irreversible injury may be obscured when large cell populations are studied. To overcome this drawback, single cultured hepatocytes and myocytes during hypoxic
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How to isolate cardiac myocytes
Cardiovascular Research, 1994A complete technique is described for the isolation of myocytes from mammalian hearts using the Langendorff perfusion technique. The use of calcium-free solution containing collagenase and protease, followed by low calcium solution, consistently results in a large number of calcium tolerant myocytes which are well suited for long periods of ...
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