Results 141 to 150 of about 78,026 (273)

Baseline serum ferritin predicts myocardial iron uptake following intravenous iron therapy – a hypothesis‐generating study

European Journal of Heart Failure, EarlyView.
Abstract Aims Many patients with heart failure (HF) are iron‐deficient. Intravenous (IV) iron therapy improves symptoms and reduces hospitalizations for HF. Several mechanisms have been proposed, including myocardial iron repletion. However, it is unknown if serum iron markers predict the extent of this repletion.
Julio Nunez, Anna Mollar, Mayra Vera‐Aviles, Syeeda Kabir, Akshay Shah, Paolo Polzella, Michael Desborough, Ingrid Cardells, Gema Miñana, Irene del Canto, Vanessa Ferreira, Stefan Piechnik, Alicia Maceira, Samira Lakhal‐Littleton   +13 more
wiley   +1 more source

Myonuclear alterations associated with exercise are independent of age in humans

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Structural and mechanical properties of myonuclei in trained young and aged individuals. In skeletal muscle fibres from trained individuals, myonuclei are more spherical, have greater lamin A and are stiffer compared to untrained counterparts.
E. Battey, J. A. Ross, A. Hoang, D. G. S. Wilson, Y. Han, Y. Levy, R. D. Pollock, M. Kalakoutis, J. N. Pugh, G. L. Close, G. M. Ellison‐Hughes, N. R. Lazarus, T. Iskratsch, S. D. R. Harridge, J. Ochala, M. J. Stroud   +15 more
wiley   +1 more source

Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult tissue necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during ...
Marc A. Beal, Melanie Coughlan, Andrée Nunnikhoven, Reena Corbane, Cathy Cummings‐Lorbetskie, Andrea Rowan‐Carroll, Tanvi Sharma, Andrew Williams, Jessie R. Lavoie, Andrew Stalker, Asish Mohapatra, Matthew J. Meier   +11 more
wiley   +1 more source

A Simple and Fast Optical Clearing Method for Whole‐Mount Fluorescence In Situ Hybridization (FISH) Imaging

Journal of Biophotonics, EarlyView.
In this article, we present 3D‐LIMPID‐FISH: a simple and fast optical clearing method for acquiring 3D images of fluorescence in situ hybridization probes. Figures and movies are provided to showcase the technology, and a detailed protocol is provided to replicate the result.
Junwoo Suh, Yehe Liu, Jordan Smith, Michiko Watanabe, Andrew M. Rollins, Michael W. Jenkins   +5 more
wiley   +1 more source

Effects of 1267 nm Illumination on Microcirculation Regulatory Mechanisms

Journal of Biophotonics, EarlyView.
The question of activation of blood flow regulatory mechanisms during laser illumination remains open to date. This study showed the effect of laser exposure on the microcirculatory bed, which appears in the form of endothelium‐dependent vascular activity.
Lyubov Eratova, Irina Makovik, Viktor Dremin   +2 more
wiley   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Improved and Automated Detection of Papillary Muscle Infarction Using Joint Bright‐ and Black‐Blood Late Gadolinium Enhancement MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Papillary muscle infarction (PMI) has been linked to significantly increased mortality and is associated with ventricular arrhythmias and mitral regurgitation. Reference bright‐blood late gadolinium enhancement (LGE) imaging provides poor scar‐to‐blood contrast, making PMI visualization challenging. Black‐blood LGE imaging overcomes
Théo Richard, Victor de Villedon de Naide, Victor Nogues, Thaïs Génisson, Kalvin Narceau, Kun He, Rabea Klaar, Baptiste Durand, Thibault Boullé, Guillaume Poirot, Soumaya Sridi, Jean‐David Maes, Marion Constantin, Kinan Kneizeh, Konstantinos Vlachos, Guido Caluori, Pierre Jaïs, Matthias Stuber, Hubert Cochet, Aurelien Bustin   +19 more
wiley   +1 more source

Time‐course manganese chloride biodistribution and manganese‐induced MRI contrast in mouse organs

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To optimize manganese‐enhanced MRI (MEMRI) in mice by profiling the time‐course biodistribution and associated T1 contrast enhancement of MnCl2 injected subcutaneously to avoid abrupt spikes in blood manganese levels. Methods Manganese (Mn) biodistribution and Mn‐induced T1 contrast in healthy female adult CD‐1 mice were investigated ...
Keyu Zhuang, Kyle D. W. Vollett, Minbo Hou, Yan Chang, Hai‐Ling Margaret Cheng   +4 more
wiley   +1 more source

Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

PROTEOMICS, EarlyView.
ABSTRACT Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hypertension‐related complications.
De‐Wei An, Dries S. Martens, Gontse G. Mokwatsi, Yu‐Ling Yu, Babangida S. Chori, Agnieszka Latosinska, Godsent Isiguzo, Susanne Eder, Dong‐Yan Zhang, Gert Mayer, Ruan Kruger, Jana Brguljan‐Hitij, Christian Delles, Catharina M. C. Mels, Katarzyna Stolarz‐Skrzypek, Marek Rajzer, Peter Verhamme, Aletta E. Schutte, Tim S. Nawrot, Yan Li, Harald Mischak, Augustine N. Odili, Jan A. Staessen   +22 more
wiley   +1 more source

Hormone Therapy Usage Is Associated With Adverse Cardiovascular Events in Prostate Cancer Patients of the All of Us Research Program Cohort

The Prostate, EarlyView.
ABSTRACT Background Hormone therapy (HT) has greatly improved overall survival for prostate cancer patients, but may also influence cardiovascular health in an already high‐risk population. Methods This retrospective cohort study examined participants in the All of Us Research Program with prostate cancer, had no prior history of adverse cardiovascular
Yuanchu J. Yang, Chenjie Zeng, Kerry R. Schaffer, Tam C. Tran, Peter J. Sauer, Lincoln A. Brown, Ben H. Park, Joshua C. Denny   +7 more
wiley   +1 more source