Results 171 to 180 of about 144,200 (309)

Measurement and control of mechanics of cardiac trabeculae secured by light‐curable hydrogel

Experimental Physiology, EarlyView.
Abstract Isolated cardiac trabeculae are small heart muscle tissue preparations, which have been widely used in in vitro studies of mechanics and energetics function of cardiac muscle. Current instruments for such experimentation often (1) involve delicate mounting of the muscle, (2) constrain investigations to one muscle at a time, and thus (3) limit ...
Emily J. Clark Murphy, Toan Pham, June‐Chiew Han, Kenneth Tran, Khoon S. Lim, Poul M. F. Nielsen, Andrew J. Taberner   +6 more
wiley   +1 more source

The mechanism of action of digoxin requires the sodium-dependent inactivation of the sodium-calcium exchanger. [PDF]

Sci Adv
Scranton K, John S, Angelini M, Zhang R, Schwingshackl A, Goldhaber JI, Olcese R, Ottolia M.   +7 more
europepmc   +1 more source

The efficacy and physiological bases of small muscle mass exercise in health and disease

Experimental Physiology, EarlyView.
Abstract The conventional approach to aerobic exercise prescription involves large muscle mass exercise and the manipulation of variables such as training intensity, duration and frequency to promote desired adaptations. However, during whole‐body exercise, central limitations (i.e., neural, pulmonary and/or cardiac) constrain exercise tolerance and ...
Callum G. Brownstein
wiley   +1 more source

PIEZO Force Sensors and the Heart. [PDF]

Cold Spring Harb Perspect Biol
McGrane A, Murray M, Bartoli F, Giannoudi M, Conning-Rowland M, Stewart L, Levelt E, Cubbon RM, Dall'Armellina E, Griffin KJ, Herum KM, Smith AJ, Beech DJ.   +12 more
europepmc   +1 more source

Cardiac‐specific Kv1.1 deficiency alters cardiomyocyte electrophysiology without modifying overall cardiac function or arrhythmia susceptibility

Experimental Physiology, EarlyView.
Abstract The leading cause of epilepsy‐related mortality is sudden unexpected death in epilepsy (SUDEP), resulting from seizure‐induced cardiorespiratory arrest by mechanisms that remain unresolved. Mutations in ion channel genes expressed in both brain and heart represent SUDEP risk factors because they can disrupt neural and cardiac rhythms ...
Kelsey Halvorson, Man Si, Krystle Trosclair, Ellen Aughenbaugh, Maxine Parkinson, Nicole M. Gautier‐Hall, Megan Watts, Frederica Kizek, Md. Shenuarin Bhuiyan, Paari Dominic, Kathryn A. Hamilton, Edward Glasscock   +11 more
wiley   +1 more source

A model for the human fetal ventricular myocyte electrophysiology. [PDF]

PLoS Comput Biol
Avezzú A, Longobardi S, Alvarez-Laviada A, Schultz F, Gorelik J, Williamson C, Niederer SA.   +6 more
europepmc   +1 more source

Ghrelin protects against cell death in myocardial ischaemia: Emerging role of microRNA

Experimental Physiology, EarlyView.
Abstract Acute myocardial infarction (MI) accelerates cardiomyocyte apoptosis, which underpins ventricular remodelling and dysfunction. The hormone ghrelin mitigates this remodelling, but the mechanisms remain unclear. Specific microRNAs (miRs) are key modulators and reliable biomarkers of early‐stage apoptosis.
Rajesh Katare, Jeffrey R. Erickson, Daryl O. Schwenke   +2 more
wiley   +1 more source

The electrophysiology of ventricular cell pairs. [PDF]

Pflugers Arch
Zaniboni M.
europepmc   +1 more source

An update on pacemaking in the myometrium

The Journal of Physiology, EarlyView.
Abstract figure legend The spread of multiple electrical signals (panel A, blue‐to‐red indicates increasing electrical excitability) that are spatiotemporally distinct, yet in‐phase with the excitatory episode, determines action potential shape and form (panel B, as recorded by single cell microelectrodes) and ensures contractile amplitude and duration
Susan Wray, Michael J. Taggart
wiley   +1 more source

Atrial TRPM2 Channel-Mediated Ca²⁺ Influx Regulates ANP Secretion and Protects Against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis. [PDF]

Cells
Numata T, Tagashira H, Sato-Numata K, Hermosura MC, Abe F, Sakai A, Yamamoto S, Watanabe H.   +7 more
europepmc   +1 more source