The Journal of Physiology, EarlyView.Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi +11 more
wiley +1 more source
Heart Failure and Arrhythmias: Circadian and Epigenetic Interplay in Myocardial Electrophysiology. [PDF]
Int J Mol SciZhu C, Li S, Zhang H.
europepmc +1 more source
14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses
The Journal of Physiology, EarlyView.Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley +1 more source
Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II (CaMKII) Regulates Basal Cardiac Pacemaker Function: Pros and Cons. [PDF]
CellsVinogradova TM, Lakatta EG.
europepmc +1 more source
Repolarization adaptation to rapid change in heart rate in human models – a review
The Journal of Physiology, EarlyView.Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt +5 more
wiley +1 more source
PDE4D inhibition ameliorates cardiac hypertrophy and heart failure by activating mitophagy. [PDF]
Redox BiolFu J +11 more
europepmc +1 more source
Atrial fibrosis in atrial fibrillation: Mechanisms, mapping techniques and clinical applications
The Journal of Physiology, EarlyView.Abstract figure legend Summary of key aspects of atrial fibrosis in atrial fibrillation, highlighting atrial fibrosis as a hallmark of atrial fibrillation (AF). (1) Different types of fibrosis (blue), illustrating reparative and reactive fibrosis; (2) fibrosis detection techniques (green), illustrating late gadolinium enhancement cardiac magnetic ...
Caterina Vidal Horrach +8 more
wiley +1 more source
Impact of Overnight Storage of Human Atrial Myocytes on Intracellular Calcium Homeostasis and Electrophysiological Utility. [PDF]
BiomoleculesAceituno C +5 more
europepmc +1 more source
Mechanism of Arrhythmogenesis Driven by Early After Depolarizations in Cardiac Tissue. [PDF]
PLoS Comput BiolStein J, Greene D, Fenton F, Shiferaw Y.
europepmc +1 more source
Postpartum QT Prolongation in a Long QT Syndrome Type 1 Patient
Annals of Noninvasive Electrocardiology, Volume 30, Issue 4, July 2025.We present the case of an LQT1 patient with a previous cardiac event during the postpartum period. Performance of electrocardiograms and Estradiol as well as Progesterone levels revealed prolonged QT intervals postpartum correlating to declining sex hormone levels elevate the risk for arrhythmic events in this period.
Lilli C. Wiedenmann +2 more
wiley +1 more source