Results 231 to 240 of about 141,107 (310)

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Possible Right Coronary Artery Supply to Pericardial Adipose Tissue Adjacent to an Abnormal Proximal Ascending Aortic Wall: A Case Report. [PDF]

Cureus
Takeuchi H.
europepmc   +1 more source

Mitochondrial physiology in cardiac muscle of deer mice native to high altitude

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem, Samuel G. Robichaud, Simon G. Lamarre, Graham R. Scott   +3 more
wiley   +1 more source

Dynamic microRNA Signatures as Biomarkers for Cardiac Ischemia and Remodeling. [PDF]

Int J Mol Sci
Rodríguez-Serrano M, Martín-García E, Alonso-Andrés P, Conde-Moreno E, Pian H, Del Moral-Salmoral J, Alcharani N, Menacho-Román M, Crespo-Toro L, Ramos-Muñoz ME, Zaragoza C, Rincón LM, Barderas MG, García-Bermejo ML.   +13 more
europepmc   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Increased Intermembrane Space [Ca²⁺] Drives Mitochondrial Structural Damage in CPVT. [PDF]

Circ Res
Hamilton S, Terentyeva R, Veress R, Perger F, Nichtova Z, Bannister M, Wang J, Quiggle S, Battershell R, Gorr MW, Györke S, Choi BR, George CH, Belevych AE, Csordás G, Terentyev D.   +15 more
europepmc   +1 more source

Electrodiffusion in cardiac intercalated disc nanostructures alters cell–cell action potential transmission via ephaptic coupling: A model study

The Journal of Physiology, EarlyView.
Abstract figure legend Ephaptic phenomena in a high‐resolution model of the cardiac intercalated disc. Meshed representation of a tortuous intercalated disc that was generated based on electron and super‐resolution microscopy data. Na+ channels (red) and gap junctions (green) are heterogeneously distributed, with additional regions of reduced ion ...
Ena Ivanovic, Marina Vannucci, Nicolae Moise, Seth H. Weinberg, Jan P. Kucera   +4 more
wiley   +1 more source

Second-generation antipsychotics - Cardiac ion channel modulation and QT interval disturbances: A review. [PDF]

Biomol Biomed
Erkan O, Dai AS, Ozturk N, Ozdemir S.
europepmc   +1 more source

Intercalated disk structure, tissue heterogeneity and ion channel distribution modulate conduction and local calcium influx

The Journal of Physiology, EarlyView.
Abstract figure legend A, three‐dimensional representation of cardiac intercalated disk, reduced to a 100‐partition, computationally efficient network representation. B, ion dynamics within intercalated disk extracellular cleft space. C, rapid pacing leads to localized conduction block in tissue with regions of perturbed intercalated disk (ID ...
Nicolae Moise, Heather L. Struckman, James W. Smyth, Gregory S. Hoeker, Steven Poelzing, Rengasayee Veeraraghavan, Seth H. Weinberg   +6 more
wiley   +1 more source

Gene Testing Across Phenotypes of Hypertrophic Cardiomyopathy. [PDF]

JACC Case Rep
Bavishi A, Nazif K, Martinez MW.
europepmc   +1 more source