Results 71 to 80 of about 144,200 (309)

Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade [PDF]

, 2003
<b>1.</b> 5-Hydroxytryptamine (5-HT) has been postulated to play a proarrhythmic role in the human atria via stimulation of 5-HT₄ receptors.
Andrew C Rankin, Antony J Workman, BERS, BLONDEL, Davide Pau, DAWODU, GRAMMER, GRIMM, HALL, HEGDE, JAHNEL, JAHNEL, JIA, JOSEPH, KAMATH, Kathleen A Kane, KAUMANN, KAUMANN, KAUMANN, LEVY, MEDHURST, MOE, NATTEL, NEHER, OUADID, RAHME, SANDERS, TONINI, WANG, WANGEMANN, WORKMAN, WORKMAN, YUE   +32 more
core   +2 more sources

Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion [PDF]

Circulation Research, 2017
Rationale: The sympathetic nervous system is a major mediator of heart function. Intercalated discs composed of desmosomes, adherens junctions, and gap junctions provide the structural backbone for coordinated contraction of cardiac myocytes. Objective:
Camilla, Schinner, Franziska, Vielmuth, Vera, Rötzer, Matthias, Hiermaier, Mariya Y, Radeva, Thu Kim, Co, Eva, Hartlieb, Andreas, Schmidt, Axel, Imhof, Ahmed, Messoudi, Anja, Horn, Angela, Schlipp, Volker, Spindler, Jens, Waschke   +13 more
openaire   +2 more sources

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats

International Journal of Cell Biology, 2011
ATP-sensitive potassium channels (KATP) protect the myocardium from hypertrophy induced by pressure-overloading. In this study, we determined the effects of these channels in volume-overloading.
Zikiar V. Alvin, Richard M. Millis, Wissam Hajj-Mousssa, Georges E. Haddad   +3 more
doaj   +1 more source

It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3

Communications Biology, 2023
The occurrence of NO/cGMP signalling in cardiac cells is a matter of debate. Recent measurements with a FRET-based cGMP indicator in isolated cardiac cells revealed NO-induced cGMP signals in cardiac fibroblasts while cardiomyocytes were devoid of these ...
Lukas Menges, Jan Giesen, Kerem Yilmaz, Evanthia Mergia, Annette Füchtbauer, Ernst-Martin Füchtbauer, Doris Koesling, Michael Russwurm   +7 more
doaj   +1 more source

A protocol for rapid and parallel isolation of myocytes and non-myocytes from multiple mouse hearts

STAR Protocols, 2021
Summary: This protocol features parallel isolation of myocytes and non-myocytes from murine hearts. It was designed with considerations for (1) time required to extract cardiac cells, (2) cell viability, and (3) protocol scalability.
Gabriella E. Farrugia, Micheal A. McLellan, Kate L. Weeks, Aya Matsumoto, Charles D. Cohen, Crisdion Krstevski, Taylah L. Gaynor, Adam C. Parslow, Julie R. McMullen, Alexander R. Pinto   +9 more
doaj   +1 more source

A modeling framework for contact, adhesion and mechano-transduction between excitable deformable cells

, 2017
Cardiac myocytes are the fundamental cells composing the heart muscle. The propagation of electric signals and chemical quantities through them is responsible for their nonlinear contraction and dilatation. In this study, a theoretical model and a finite
Gizzi, Alessio, Lenarda, Pietro, Paggi, Marco   +2 more
core   +1 more source

Gender differences in cardiac left ventricular mass and function: clinical and experimental observations [PDF]

, 2014
Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats.
Aiello, Ernesto Alejandro, Diaz, Alejandro, Ennis, Irene Lucia, Escudero, Eduardo Manuel, Orlowski, Alejandro, Pinilla, Oscar Andres   +5 more
core   +2 more sources

Mechano‐chemo‐transduction in cardiac myocytes [PDF]

The Journal of Physiology, 2017
AbstractThe heart has the ability to adjust to changing mechanical loads. The Frank–Starling law and the Anrep effect describe exquisite intrinsic mechanisms the heart has for autoregulating the force of contraction to maintain cardiac output under changes of preload and afterload.
Ye Chen‐Izu, Leighton T. Izu
openaire   +2 more sources

Reprogramming the Myocardial Infarction Conductive Microenvironment with Superconductive Ionic Patch for Cardiac Function Repair

Advanced Science, EarlyView.
A super‐conductive ionic patch reprograms the post‐infarction microenvironment by enabling stable ionic migration and electrical signal transmission within damaged myocardium. The patch rapidly adheres to cardiac tissue, enhances conduction velocity, suppresses excitation‐contraction decoupling, and promotes structural and functional cardiac repair in ...
Changyong Wang, Zhuang Zhang, Qi Yin, Changgeng Xu, Linlin Liang, Siwei Li, Yuwei Zhao, Chunlan Wang, Jin Zhou   +8 more
wiley   +1 more source