Results 241 to 250 of about 287,296 (284)

Leiomyoblastoma of the uterus: an immunohistochemical and electron microscopic study of distinctive tumours with immature smooth muscle cell differentiation mimicking fetal uterine myocytes

Histopathology, 2003
Aims:  We present three distinctive uterine tumours which exhibited immature smooth muscle differentiation mimicking smooth muscle cells of the fetal uterus.Methods and results:  The patients were 45, 46 and 49 years old, and all of them had simple hysterectomies.
Go Ogura, Toshimitsu Suzuki, Kazuo Watanabe   +2 more
openaire   +4 more sources

Inactivation of Calcium Channels in Vascular Smooth Muscle Myocytes

Cell Biochemistry and Biophysics, 2006
Many of the structural domains involved in Ca2+ channel (CACN) inactivation are also involved in determining their sensitivity to antagonist inhibition. We hypothesize that differences in inactivation properties and their structural determinants may suggest candidate domains as targets for the development of novel, selective antagonists.
Robert H. Cox, Martin Kathrins
openaire   +3 more sources

Adrenergic stimulation of diacylglycerol production in genital tract smooth muscle myocytes

In Vitro Cellular & Developmental Biology - Animal, 1993
Diacylglycerol (DAG) production has not been reported in previous studies that have characterized inositol phosphate production during alpha-1 adrenergic receptor signal transduction in the DDT1 MF-2 genital tract myocytes. The current study sought to measure norepinephrine (NE)-stimulated DAG production in these transformed myocytes utilizing thin ...
Mark Phillippe, R. Austin, Laura DiGiovonni   +2 more
openaire   +4 more sources

Three-Dimensional Culture of Human Uterine Smooth Muscle Myocytes on a Resorbable Scaffolding

Tissue Engineering, 2003
The objective of this study was to develop a three-dimensional culture system for the study of human myometrial physiology. Primary cell lines were initiated from human myometrium obtained at the time of term cesarean delivery. After several passages, cells were seeded onto a polyglactin-910 (Vicryl) mesh and maintained in culture.
Ralph Schumann, Peisheng Zhang, Roger C. Young   +2 more
openaire   +3 more sources

Smooth Muscle Myocyte Ultrastructure and Contractility

2012
Smooth muscles forming the walls of hollow organs have unique mechanical properties and are adapted to carry out their diverse specialized functions. This chapter is an overview of the basic ultrastructural and functional distinguishing characteristics of smooth muscle (SM). Evidence for a sliding filament mechanism of contraction is summarized.
Avril V. Somlyo, Marion J. Siegman
openaire   +2 more sources

Vesnarinone Inhibits Adenosine Uptake in Endothelial Cells, Smooth Muscle Cells and Myocytes, and Mediates Cytoprotection

Journal of Molecular and Cellular Cardiology, 1997
Vesnarinone is a novel synthetic inotropic agent. Recently, it has been reported that vesnarinone inhibits adenosine uptake in the B-lymphocytoid cell line. Since extracellular adenosine is cardioprotective, we examined whether vesnarinone inhibits adenosine uptake in cells constituting the cardiovascular system. 1 microCi of -3H-adenosine was added to
Tetsuo Minamino, Naohiro Terada, Yuji Okuyama, Masafumi Kitakaze, Taku Kambayashi, Miranda Fong, Masatsugu Hori, Koichi Node, Masuhiro Yoshitake   +8 more
openaire   +3 more sources

The effects of myocyte enhancer factor 2A gene on the proliferation, migration and phenotype of vascular smooth muscle cells

Cell Biochemistry and Function, 2011
The genetic basis for the phenotypic switching of vascular smooth muscle cells (VSMCs) is unclear in atherosclerosis. Recent studies showed that the 21‐base pair deletion mutation (Δ21) in myocyte enhancer factor 2A (MEF2A) gene could be an inherited marker for coronary artery disease. MEF2A mutation may affect the phenotypic switching of VSMCs.
Shui-ping Zhao, Daoquan Peng, Wang Zhao
openaire   +2 more sources

Myocyte Enhancer Binding Factor-2 Expression and Activity in Vascular Smooth Muscle Cells

Circulation Research, 1996
Abstract Proliferation and phenotypic modulation of smooth muscle cells (SMCs) are major components of the vessel’s response to injury in experimental models of restenosis. Some of the growth factors involved in restenosis have been identified, but to date little is known about the transcription factors that ultimately regulate
Joseph M. Miano, A. Daniel Johnson, Ward Casscells, Eric N. Olson, John J. Schwarz, Weizhen Bi, Anthony B. Firulli   +6 more
openaire   +3 more sources

A mechanism for testosterone modulation of alpha-1 adrenergic receptor expression in the DDT1 MF-2 smooth muscle myocyte

Molecular and Cellular Biochemistry, 1991
Previous reports have confirmed that steroid hormones modulate the expression of adrenergic receptors on the surface of smooth muscle myocytes. The present study was undertaken to evaluate the mechanism by which testosterone modulates alpha-1 adrenergic receptor expression in the DDT1 MF-2 transformed smooth muscle cell.
Shrikar Bangalore, Trevania Saunders, Mark Phillippe   +2 more
openaire   +2 more sources

Early intracellular signaling events induced by in vitro metreleptin administration in cardiac myocytes and uterine smooth muscle cells.

Cellular and molecular biology (Noisy-le-Grand, France), 2015
Intracellular signaling pathways regulated by leptin have largely been studied in metabolically important organs such as adipose tissue and peripheral blood mononuclear cells, suggesting that leptin plays a key role in pathophysiology of insulin resistance.
Yoon E. Choi, Soon-Jae Park, Seung Kug Choi, Hyun Seuk Moon   +3 more
openaire   +3 more sources