Results 111 to 120 of about 73,235 (299)

A Metal‐Polyphenol Self‐Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate‐Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing

Advanced Science, EarlyView.
A thrombin‐functionalized copper‐polydopamine nanofiber sponge integrates rapid hemostasis, mild photothermal antibacterial therapy, stimulus‐responsive Cu2+ release, chemodynamic oxidative stress, and macrophage immunomodulation. This multifunctional dressing suppresses infection, regulates inflammation, promotes angiogenesis and re‐epithelialization,
Ziwei Zhang, Feng Qin, Xiaomeng Zhang, Xueqin Shuang, Jiahua Zhou, Ming Cheng, Baicheng Lu, Mingyue Song, Yuntian Bai, Dianying Zhang, Ming Li, Yanhua Wang   +11 more
wiley   +1 more source

Fibroblasts in fibrosis: novel roles and mediators

Frontiers in Pharmacology, 2014
Fibroblasts are the most common cell type of the connective tissues found throughout the body and the principal source of the extensive extracellular matrix (ECM) characteristic of these tissues.
Ryan Thomas Kendall, Carol A. Feghali-Bostwick   +1 more
doaj   +1 more source

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Predictable fibroblast tension generation by measuring compaction of anchored collagen matrices using microscopy and optical coherence tomography

Cell Adhesion & Migration, 2019
The anchored fibroblast-populated collagen matrix (aFPCM) is an appropriate model to study fibrocontractive disease mechanisms. Our goal was to determine if aFPCM height reduction (compaction) during development is sufficient to predict tension ...
Melville B. Vaughan, Gang Xu, Tracy L. Morris, Pratiksha Kshetri, Jing X. Herwig   +4 more
doaj   +1 more source

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-β1 Stimulation

Frontiers in Pharmacology, 2017
Introduction: Epigenetic regulation of fibrogenesis through post-translational histone modifications (marks) may be a key determinant of progression in renal disease. In this study, we examined the distribution and acquisition of histone 3 Lysine 9 (H3K9)
Timothy D. Hewitson, Timothy D. Hewitson, Stephen G. Holt, Stephen G. Holt, Sven-Jean Tan, Belinda Wigg, Chrishan S. Samuel, Edward R. Smith, Edward R. Smith   +8 more
doaj   +1 more source

Mechanical Tension Controls Granulation Tissue Contractile Activity and Myofibroblast Differentiation

, 2001
We have examined the role of mechanical tension in myofibroblast differentiation using two in vivo rat models. In the first model, granulation tissue was subjected to an increase in mechanical tension by splinting a full-thickness wound with a plastic ...
Dominique Mastrangelo, Hinz, Boris, Iselin, Christophe, Giulio Gabbiani, Christophe E. Iselin, Boris Hinz, Chaponnier, Christine, Gabbiani, Giulio, Christine Chaponnier, Mastrangelo, Domenico   +9 more
core   +1 more source

Resveratrol reduces myofibroblast arrhythmogenicity [PDF]

, 2010
Background: Among grape skin polyphenols, trans-resveratrol (RES) has been reported to slow the development of cardiac fibrosis and to affect myofibroblast (MFB) differentiation.
Nicolò Salvarani, Rohr, Stephan, Rosker, Christian, Stephan Rohr, Salvarani, Nicolò, Christian Rosker   +5 more
core   +2 more sources

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source

Myofibroblast-Like CAFs in Metastatic Lymph Nodes Drive Tumor Stemness and Poor Prognosis in Head and Neck Cancer. [PDF]

Cancer Sci
Compared with PT‐CAFs, LN‐CAFs exhibited a myofibroblast‐like phenotype, enhanced tumor stemness‐promoting activity, and fibrosis‐, EMT‐, and hypoxia‐related transcriptomic signatures. LN‐CAF‐related gene signatures were independently associated with poor prognosis in head and neck squamous cell carcinoma.
Hagiwara H, Takahashi H, Kawabata-Iwakawa R, Uchida M, Tada H, Matsuyama T, Motegi M, Tomidokoro Y, Chikamatsu K.   +8 more
europepmc   +2 more sources

Association of DPP4 with esophageal stricture progression and the Hippo‐YAP pathway

Animal Models and Experimental Medicine, EarlyView.
This study establishes a comprehensive translational platform for esophageal stricture (ES) research by integrating a novel rat model with clinically relevant porcine validation. This study identifies DPP4 as a gene of interest associated with ES following endoscopic submucosal dissection, demonstrating that prophylactic DPP4 inhibition attenuates ...
Rui Wu, Chen Wang, Hui‐Min Tao, Jin Huang, Wei‐Qin Li, Zhi‐Ning Fan   +5 more
wiley   +1 more source