Precision Medical Sciences, EarlyView.Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley +1 more source
MMT: A Potential Mechanism of Myocardial Fibrosis - Regulation of the TGF-β1/Smad3 Pathway and Prospects for Targeted Therapy. [PDF]
Rev Cardiovasc MedZou MR +5 more
europepmc +1 more source
Primary BPH Stromal Cell Cultures Exhibit Heightened Androgen‐Responsiveness
The Prostate, EarlyView.ABSTRACT Background Benign prostatic hyperplasia (BPH) is the most common disease in aging males. BPH growth is androgen‐dependent, and it appears that androgens preferentially stimulate the growth of BPH as compared to normal prostate. The mechanism of preferential androgen stimulation of BPH growth is not clear.
Wei Chen +9 more
wiley +1 more source
Small, EarlyView.By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo +15 more
wiley +1 more source
Decoding fibroblast activation: Transcriptional networks in hepatic stellate cells and across fibrotic organs (Review). [PDF]
Int J Mol MedCharoenthanakitkul D, Ariyachet C.
europepmc +1 more source
Biomarkers to predict outcomes in diabetic foot ulcers
VIEW, EarlyView.Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro +6 more
wiley +1 more source
Expression of Concern: MGST2hi PMNs mediate NETs and drive pericyte-to-myofibroblast transition in RA-ILD. [PDF]
Am J Respir Cell Mol Bioleuropepmc +1 more source
The role of glutamine metabolism in the pathogenesis of idiopathic pulmonary fibrosis and its therapeutic potential. [PDF]
Front OncolLi J.
europepmc +1 more source
VIEW, EarlyView.Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan +4 more
wiley +1 more source
Single-cell transcriptomics and a boundary wound model reveal temporal decoupling and microenvironmental heterogeneity in radiation-induced fibrosis. [PDF]
Front OncolCao B, Liu P, Tan Y, Wei Y.
europepmc +1 more source