Results 211 to 220 of about 87,228 (284)

Circumscribed Morphea Successfully Treated With Excimer Laser: Analysis of Histopathological Changes

The Journal of Dermatology, EarlyView.
ABSTRACT Localized scleroderma (LSc) is an autoimmune condition characterized by localized cutaneous sclerosis, sometimes extending into deeper tissues. Phototherapy, including excimer laser therapy (ELT), is considered an effective and minimally invasive treatment option for patients without extracutaneous involvement.
Takuya Takahashi, Takehiro Takahashi, Yuichiro Segawa, Kenta Oka, Toshiya Takahashi, Yoshihide Asano   +5 more
wiley   +1 more source

Spatiotemporal dynamics of mammalian wound healing. [PDF]

Cell Discov
Agramunt J, Kang Y, Rinkevich Y.
europepmc   +1 more source

Sensitizer‐Induced Basophils Accelerate Skin Re‐Epithelialization via IL‐4/IL‐13‐Mediated Macrophage Polarization

Allergy, EarlyView.
Oxazolone exposure drives rapid basophil recruitment to wounded skin, accelerating re‐epithelialization, angiogenesis, and tissue regeneration. Basophils are the dominant early source of IL‐4 and IL‐13 in the wound microenvironment. Basophil‐derived IL‐4/IL‐13 promote macrophage polarization toward a pro‐repair M2 phenotype, enabling efficient wound ...
Yufei Zhang, Xueting Peng, Kaixuan Ren, Shiran Kang, Zihan Xue, Yazhuo Li, Zhu Yan, Rongfang Feng, Min Gao, Qin Chen, Xiaoying Ning, Fan Bai, Liesu Meng, Yumin Xia, Yale Liu   +14 more
wiley   +1 more source

Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology. [PDF]

J Exp Med
Mbano IM, Liu N, Wadsworth MH, Chambers MJ, Mpotje T, Asowata OE, Nyquist SK, Nargan K, Ramsuran D, Karim F, Hughes TK, Bromley JD, Krause R, Naidoo T, Tezera LB, Reichmann MT, Ganchua SK, Kløverpris HN, Dullabh KJ, Madansein R, Triana S, Steyn AJC, Berger B, Marakalala MJ, Pollara G, Fortune SM, Flynn JL, Elkington PT, Shalek AK, Leslie A.   +29 more
europepmc   +1 more source

Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

British Journal of Pharmacology, EarlyView.
In this study, nintedanib reduced lung fibrosis in a rat double‐hit bleomycin‐induced model. Transcriptomic analysis revealed two key gene signatures related to the effect of the molecule: one involving mesenchymal cells affecting known fibrotic pathways and another linking mainly macrophages to lipid metabolism.
Martina Bonatti, Vanessa Pitozzi, Paola Caruso, Silvia Pontis, Maria Gloria Pittelli, Caterina Frati, Denise Madeddu, Federico Quaini, Costanza Anna Maria Lagrasta, Ilaria Minato, Emanuela Bocchi, Maurizio Civelli, Gino Villetti, Marcello Trevisani, Barbara Montanini   +14 more
wiley   +1 more source

Suppression of CSF2RA macrophage polarisation impacts pathological cardiac remodelling in mice. [PDF]

Sci Rep
Kremastiotis G, Li Y, Bond A, Shanahan D, Gregoli KD, Poole AW, George SJ, Johnson JL.   +7 more
europepmc   +1 more source

β3‐adrenoceptor agonism exerts lung protection in a rat model of bronchopulmonary dysplasia

British Journal of Pharmacology, EarlyView.
The β3‐adrenoceptors agonist BRL37344 promotes lung maturation, preventing the progression of experimental bronchopulmonary dysplasia. Absract Background and Purpose Bronchopulmonary dysplasia (BPD) affects premature newborns, particularly those receiving supplemental oxygen therapy.
Alessandro Pini, Patrizia Nardini, Virginia Zizi, Marta Molino, Maura Calvani, Francesco Carrozzo, Rachele Amato, Daniele Guasti, Denise Biagini, Fabio di Francesco, Ludovico Silvestri, Alessandra Franceschini, Daniele Bani, Elisa Imbimbo, Luca Filippi   +14 more
wiley   +1 more source

Integration of cAMP and TRPV4 Signaling to Optimize Collagen Remodeling for Management of Fibrosis. [PDF]

Cells
Di Raimo C, McCulloch C.
europepmc   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source