Results 241 to 250 of about 87,228 (284)

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Minimally invasive glaucoma surgery: Demystifying trabecular meshwork complex and the concept of surgical management of glaucoma. [PDF]

Indian J Ophthalmol
Parihar JKS, Kumawat A, Parihar AKS, Kaushik J.   +3 more
europepmc   +1 more source

A Novel Fibroblast Activation Protein‐Based Algorithm to Assess Fibrosis in Metabolic Dysfunction–Associated Steatotic Liver Disease

Journal of Gastroenterology and Hepatology, EarlyView.
To improve triage for liver fibrosis in MASLD primary care and where elastography is unavailable, a novel algorithm, FAP Index, that requires one fibrogenesis‐relevant, rapid enzyme assay, was devised and validated. FAP Index increased advanced fibrosis risk stratification accuracy by greatly reducing the frequency of indeterminate results compared to ...
Ziqi V. Wang, Badwi B. Boumelhem, Torsten Pennell, William W. Bachovchin, Jack Hung‐Sen Lai, Sarah E. Poplawski, Harsha Chandraratna, Pieter Van Der Veken, Kate Brewer, Diana Julie Leeming, Geraldine Ooi, Jacob George, Mohammed Eslam, Leon A. Adams, Hui Emma Zhang, Geoffrey W. McCaughan, Avik Majumdar, Mark D. Gorrell   +17 more
wiley   +1 more source

Neural modulation of ocular immunity: Exploring a sympathetic‐macrophage neuroimmune link in the human ciliary body

Journal of Anatomy, EarlyView.
Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou, Claire Mackaaij, Mark van Zijverden, Hendrik A. Messal, Jeannette Ossewaarde‐van Norel, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +6 more
wiley   +1 more source

Epigenetic Reprogramming Via Sodium Butyrate Induces Corneal Myofibroblast Dedifferentiation In Vitro and Inhibits Fibrosis In Vivo. [PDF]

Invest Ophthalmol Vis Sci
Sood S, Sinha NR, Tiwari A, Ruterschmidt E, Tripathi R, Gupta S, Mohan RR.   +6 more
europepmc   +1 more source

Exosomes in Hypertrophic Scars and Keloids: Mechanisms and Therapeutic Potentials-A Narrative Review. [PDF]

J Cosmet Dermatol
Wu M, Zhang J, Xiong N, Ma Y, Yong L, Liu H, Guo Q.   +6 more
europepmc   +1 more source

Correction: Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications. [PDF]

Front Immunol
Liang X, Li Y, Tang Z, Luo Y, Liu Y.
europepmc   +1 more source

Matrix Stiffness Promotes DRP1-Mediated Myofibroblast Senescence to Drive Silica-Induced Pulmonary Fibrosis. [PDF]

Aging Cell
Zeng X, Li J, Wang J, Zhang J, Wang Y, Wang Y, Wang Y, Tian L, Zhu Z.   +8 more
europepmc   +1 more source