Results 41 to 50 of about 94,921 (285)

The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies.

Frontiers in Pharmacology, 2014
Liver fibrosis results from dysregulation of normal wound healing, inflammation, activation of myofibroblasts and deposition of extracellular matrix (ECM). Chronic liver injury causes death of hepatocytes and formation of apoptotic bodies, which in turn,
Jun eXu, Xiao eLiu, Yukinori eKoyama, Ping eWang, Tian eLan, In-Gyu eKim, In Hee eKim, Hsiao-Yen eMa, Tatiana eKisseleva   +8 more
doaj   +1 more source

TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT) [PDF]

, 2005
Background: Fibroblastic foci are characteristic features in lung parenchyma of patients with idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which underlie sites of unresolved epithelial injury and are associated with ...
A Atfi, A Desmouliere, A Desmouliere, CM Ewing, D Upadhyay, DA Vesey, DG. Hoyt, DW Powell, DW Powell, DY Rhyu, E Healy, E Piek, EE Moussad, EP Bottinger, F Strutz, G Raghu, GR Grotendorst, HW Yao, J Fan, J Gauldie, J Nightingale, J Yang, JT Allen, JT Allen, K Vleminckx, KA Foster, LH Pan, M Kelly, M Selman, M Selman, M Whitman, N Khalil, N Khalil, N Khalil, NA Bhowmick, NA Wahab, NA Wahab, NA Wahab, P Bonniaud, P Sharmila, PJ Miettinen, PJ Sime, R Derynck, R Kalluri, S Hashimoto, T Maeyama, TE King Jr, TJ Gross, V Mermall, Y Higashimoto, Y Liu   +50 more
core   +4 more sources

Fibrocytes: A Critical Review and Practical Guide

Frontiers in Immunology, 2021
Fibrocytes are hematopoietic-derived cells that directly contribute to tissue fibrosis by producing collagen following injury, during disease, and with aging.
James W. Reinhardt, Christopher K. Breuer, Christopher K. Breuer, Christopher K. Breuer   +3 more
doaj   +1 more source

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis [PDF]

, 2016
Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts ...
Brennan, PA, Clarke, J, Eliceiri, KW, Ford, K, Frampton, S, Garcia, E, Gil, J, Hanley, CJ, Herranz, N, Kabir, TD, King, EV, Lambert, DW, Lim, KP, Mellone, M, Mellows, T, Moutasim, KA, Ottensmeier, CH, Prime, SS, Thirdborough, S, Thomas, GJ, Tod, J, Underwood, TJ, Venei, V, Venturi, G, Vijayanand, P, Woelk, C, Woo, J   +26 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Exclusive expression of KANK4 promotes myofibroblast mobility in keloid tissues

Scientific Reports
Keloids are characterized by abnormal wound healing with excessive accumulation of extracellular matrix. Myofibroblasts are the primary contributor to extracellular matrix secretion, playing an essential role in the wound healing process.
Mayumi Oishi, Keiko Shinjo, Keisuke Takanari, Ayako Muraoka, Miho M. Suzuki, Miki Kanbe, Shinichi Higuchi, Katsumi Ebisawa, Kazunobu Hashikawa, Yuzuru Kamei, Yutaka Kondo   +10 more
doaj   +1 more source

Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response

eLife, 2018
Pdgfra-expressing (Pdgfra+) cells have been implicated as progenitors in many mesenchymal tissues. To determine lineage potential, we generated PdgfrartTA knockin mice using CRISPR/Cas9.
Rongbo Li, Ksenija Bernau, Nathan Sandbo, Jing Gu, Sebastian Preissl, Xin Sun   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Arterial pathology in canine mucopolysaccharidosis-I and response to therapy. [PDF]

, 2011
Mucopolysaccharidosis-I (MPS-I) is an inherited deficiency of α-L-iduronidase (IdU) that causes lysosomal accumulation of glycosaminoglycans (GAG) in a variety of parenchymal cell types and connective tissues.
Dickson, Patricia I, Ellinwood, N Matthew, Kakkis, Emil D, Lyons, Jeremiah A, McEntee, Michael F, Passage, Merry B, Wall, Jonathan S   +6 more
core   +3 more sources

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source