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Proteasome and myogenesis [PDF]
Molecular Biology Reports, 1997 In this report, we examine the involvement of the ubiquitin-proteasome pathway during fusion and differentiation of myoblast primary cell cultures. Up-regulation of proteasome was observed at the maximum fusion rate and was preceded by an increase of unidentified ubiquitin-conjugates.
Valérie Montel +3 more
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Trends in Cardiovascular Medicine, 1994
The amphibian embryo provides a convenient experimental system with which to study myogenesis. The earliest steps in the formation of axial and cardiac muscle are accessible for investigation using both embryological and molecular approaches. We review the origins of skeletal and cardiac muscle in the Xenopus embryo, the molecular markers available to ...
MOHUN T +3 more
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The amphibian embryo provides a convenient experimental system with which to study myogenesis. The earliest steps in the formation of axial and cardiac muscle are accessible for investigation using both embryological and molecular approaches. We review the origins of skeletal and cardiac muscle in the Xenopus embryo, the molecular markers available to ...
MOHUN T +3 more
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Myokines in Myogenesis and Health
Recent Patents on Biotechnology, 2012Although some myokines exert their actions on other organs in a hormone-like fashion, many of them operate locally on skeletal muscle themselves. Myokines may thereby provide a feedback loop for the muscle to regulate its own growth and regeneration allowing for adaptation to exercise training.
Henriksen, Tora +2 more
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Transcriptional diversity in myogenesis
Developmental Biology, 1976Abstract We have measured the change in RNA transcript diversity during in vivo myogenesis in the chick limb by means of saturation hybridization of whole cell RNA to nonrepetitive DNA. We find that transcript diversity decreases as proliferating myoblasts fuse to form multinucleate myotubes.
Arnold I. Caplan, Charles P. Ordahl
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The genetics of vertebrate myogenesis
Nature Reviews Genetics, 2008The molecular, genetic and cellular bases for skeletal muscle growth and regeneration have been recently documented in a number of vertebrate species. These studies highlight the role of transient subcompartments of the early somite as a source of distinct waves of myogenic precursors. Individual myogenic progenitor populations undergo a complex series
Peter D. Currie +3 more
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Experimental Cell Research, 1961
Abstract Differentiating muscle cells synthesizing myosin, the meromyosins, and actin do not concurrently synthesize DNA. Presumptive myoblasts which synthesize DNA do not concurrently synthesize myosin, the meromyosins or actin. The multinucleated skeletal muscle fiber is the product of cell fusion.
Howard Holtzer, Frank E. Stockdale
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Abstract Differentiating muscle cells synthesizing myosin, the meromyosins, and actin do not concurrently synthesize DNA. Presumptive myoblasts which synthesize DNA do not concurrently synthesize myosin, the meromyosins or actin. The multinucleated skeletal muscle fiber is the product of cell fusion.
Howard Holtzer, Frank E. Stockdale
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The molecular regulation of myogenesis
Clinical Genetics, 2000Over the past years, several studies have unraveled important mechanisms by which the four myogenic regulatory factors (MRFs: MyoD, Myf‐5, myogenin, and MRF4) control the specification and the differentiation of the muscle lineage. Early experiments led to the hypothesis that these factors were redundant and could functionally replace one another ...
Michael A. Rudnicki, Luc A. Sabourin
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Muscle: the regulation of myogenesis
Current Opinion in Genetics & Development, 1994The study of myogenesis in the embryo is a rapidly expanding field. In this context, the consequences of mutating different members of the MyoD family, together with an increasing number of observations that point to the importance of the MEF2 or RSRF family as myogenic regulators, and the identification of Pax-3 as a marker of early myogenic cells ...
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