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Role of myokines in exercise and metabolism
Journal of Applied Physiology, 2007During the past 20 yr, it has been well documented that exercise has a profound effect on the immune system. With the discovery that exercise provokes an increase in a number of cytokines, a possible link between skeletal muscle contractile activity and immune changes was established.
Pedersen, Bente Klarlund +3 more
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Myokine-mediated exercise effects: the role of myokine meteorin-like hormone (Metrnl)
Growth Factors, 2021Meterorin-like hormone (Metrnl), as a novel secreted factor, has been shown to be involved in physiological and pathophysiological processes. The behaviour of Metrnl in metabolic conditions like type 2 diabetes is conflicting. Metrnl-mediated (treatment with Metrnl) auto/paracrine actions in skeletal muscle are glucose uptake, fat oxidation and muscle ...
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The effects of myokines on osteoclasts and osteoblasts
Biochemical and Biophysical Research Communications, 2019Recently, muscle has received much attention as an endocrine organ regulating other biological targets, including the pancreas, liver, and adipose tissue. Although there is a possibility that muscle-secreting factors biochemically affect bone metabolism in a paracrine manner, the net effects of myokines on the biology of osteoclasts and osteoblasts ...
Jin Young Lee +6 more
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Impact of adipokines and myokines on fat browning
Journal of Physiology and Biochemistry, 2020Since the discovery of leptin in 1994, the adipose tissue (AT) is not just considered a passive fat storage organ but also an extremely active secretory and endocrine organ that secretes a large variety of hormones, called adipokines, involved in energy metabolism.
Sara Becerril +13 more
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FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine
PLoS ONE, 2013 Exercise provides clear beneficial effects for the prevention of numerous diseases. However, many of the molecular events responsible for the curative and protective role of exercise remain elusive. The recent discovery of FNDC5/irisin protein that is liberated by muscle tissue in response to exercise might be an important finding with regard to this ...
Arturo Roca-rivada +2 more
exaly +7 more sources
Myokines as a Factor of Physiological Inflammation
Fiziologiâ čelovekaCurrently, a new approach to the concept of “inflammation” has been formed. Increasing evidence indicates that cellular and molecular mediators of inflammation are involved in a wide range of biological processes, including tissue remodeling, metabolism, thermogenesis, and nervous system function.
A. N. Zakharova +3 more
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Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin
Frontiers in Aging Neuroscience, 2021Karina Alviña
exaly
Reply to ‘Lactate as a major myokine and exerkine’
Nature Reviews Endocrinology, 2022Lisa S. Chow +24 more
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Obesity, Myokines, and Metabolic Health
2023Noemi Malandrino, Rexford S. Ahima
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