Results 11 to 20 of about 30,577 (230)

Ghrelin in the human myometrium [PDF]

Reproductive Biology and Endocrinology, 2010
Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ghrelin inhibited human contractility in vitro.
O'Brien, Margaret, Earley, Padraig, Morrison, John J., Smith, Terry   +3 more
core   +7 more sources

Investigating the role of CFTR in human and mouse myometrium

Current Research in Physiology
Background: Abnormal cystic fibrosis transmembrane conductance regulator (CFTR) function in cystic fibrosis (CF) has been linked to airway smooth muscle abnormalities including bronchial hyperresponsiveness.
Clodagh Prendergast, Susan Wray, Daniella Dungate, Christine Martin, Andra Vaida, Elizabeth Brook, Cecilia Ani Chioma, Helen Wallace   +7 more
doaj   +2 more sources

Nitric oxide and the myometrium

Pharmacology & Therapeutics, 1996
Nitric oxide (NO) is a potent smooth muscle relaxant in blood vessels, the gastrointestinal tract and the respiratory system. Recent evidence has shown that NO has a relaxant (tocolytic) effect on myometrium. NO is produced within the female genital tract during pregnancy, and a reduction in NO synthesis may be involved in the initiation of parturition.
Norman, J., Jane Norman
openaire   +4 more sources

Physiology and Pathology of Contractility of the Myometrium [PDF]

In Vivo, 2021
Uterine atony is a serious obstetrical complication since it is the leading cause of postpartum hemorrhage. Postpartum hemorrhage (PPH) is one of the 5 major causes of postpartum mortality; therefore, it requires immediate medical intervention, independent of whether delivery occurs normally or with a cesarean section.
Koutras, A., Fasoulakis, Z., Syllaios, A., Garmpis, N., Diakosavvas, M., Pagkalos, A., Ntounis, T., Kontomanolis, E.N.   +7 more
openaire   +3 more sources

Characterization of the tissue-level Ca2+signals in spontaneously contracting human myometrium [PDF]

, 2012
In the labouring uterus, millions of myocytes forming the complex geometrical structure of myometrium contract in synchrony to increase intrauterine pressure, dilate the cervix and eventually expel the foetus through the birth canal.
Blanks, Andrew M., Thornton, S, Blanks, AM, Gullam, Joanna E., Thornton, Steven, Shmygol, A, Gullam, JE, Bru-Mercier, Gilles, Shmygol, Anatoly, Bru-Mercier, G   +9 more
core   +1 more source

Poor spontaneous and oxytocin-stimulated contractility in human myometrium from postdates pregnancies [PDF]

, 2012
Prolongation of pregnancy i.e. going more than 10 days over the estimated due date, complicates up to 10% of all pregnancies and is associated with increased risk to both mother and fetus.
Arrowsmith Sarah, Theodor Burdyga, Sarah Arrowsmith, Siobhan Quenby, Wray Susan, Wray, Susan, Weeks Andrew, Weeks, Andrew, Quenby, Siobhan, Arrowsmith, Sarah, Susan Wray, Quenby Siobhan, Burdyga, Theodor, Andrew Weeks, Burdyga Theodor   +14 more
core   +2 more sources

Comparison of the myometrial transcriptome from singleton and twin pregnancies by RNA-Seq.

PLoS ONE, 2020
Preterm birth is recognized as the primary cause of infant mortality worldwide. Twin pregnancies are significantly more at risk of preterm birth than singleton pregnancies.
Sarah Arrowsmith, Yongxiang Fang, Andrew Sharp   +2 more
doaj   +1 more source

Ca(2+)-dependent regulation of the Ca(2+) concentration in the myometrium mitochondria. I. Trifluoperazine effects on mitochondria membranes polarization and [Ca(2+)](m) [PDF]

The Ukrainian Biochemical Journal, 2016
Са2+-dependent regulation of Ca2+ exchange in mitochondria is carried out with participation of calmodulin. We have shown previously that calmodulin antagonists reduced the level of mitochondrial membrane polarization and induced increase of the ionized ...
L. G. Babich, S. G. Shlykov, A. M. Kushnarova, S. O. Kosterin   +3 more
doaj   +1 more source

Interleukin-33 regulates the endoplasmic reticulum stress of human myometrium via an influx of calcium during initiation of labor

eLife, 2022
Background: Inflammation is currently recognized as one of the major causes of premature delivery. As a member of the interleukin-1β (IL-1β) family, interleukin-33 (IL-33) has been shown to be involved in normal pregnancy as well as a variety of ...
Li Chen, Zhenzhen Song, Xiaowan Cao, Mingsong Fan, Yan Zhou, Guoying Zhang   +5 more
doaj   +1 more source

Modulating the mechanokinetics of spontaneous contractions of the myometrium of rats using calix[4]arene C-90 – plasma membrane calcium ATPase inhibitor

Біологічні студії, 2021
Introduction. Plasma membrane calcium ATPase is a constitutive structure of cells that functions as a high affinity system of releasing Са2+ ions from the cytoplasm and ensures a long-term maintenance of the basal concentration of these cations in the ...
O. V. Tsymbalyuk
doaj   +1 more source