Results 171 to 180 of about 281,418 (301)

Cytoskeletal prestress homeostasis is a biological principle that governs living cell structure and function. [PDF]

Mechanobiol Med
Rashid F, Wang N.
europepmc   +1 more source

Cortical actin dynamics: Generating randomness by formin(g) and moving [PDF]

, 2011
Wedlich-Söldner, R., Yu, H.
core   +1 more source

Arp2/3 complex and β1 integrin drive an invasive front through extracellular matrix adaptation in pancreatic cancer

International Journal of Cancer, EarlyView.
What's New? Pancreatic ductal adenocarcinoma is characterized by a dense extracellular matrix, and how invasive tumor cells overcome such biomechanical constraints remains unclear. This study identifies the actin‐related protein 2/3 complex as a key regulator of pancreatic ductal adenocarcinoma invasiveness, driving fibroblast migration through β1 ...
Xiufen Yang, Yina Qiao, Yifeng Sun, Tamer Abdelaal, Kathleen Schuck, Hend Abdelrasoul, Carolina De La Torre, Malte Hermes, Yan Dong, Jingxiong Hu, Chao Fang, Xiaoyan Huang, Christoph Kahlert, Ingrid Herr, Christoph W. Michalski, Bo Kong   +15 more
wiley   +1 more source

Cardiac Myosin Activators in Heart Failure: Experimental Advances Amid Clinical Uncertainty. [PDF]

Drug Des Devel Ther
Hou L, Lin B, Ji X, Huang A.
europepmc   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

The role of exosomal miRNA-125b derived from colon cancer-associated fibroblasts in skeletal muscle cachexia. [PDF]

PLoS One
Kim HS, Kim J, Lee B, Lee Y, Park SY, Oh BY, Cho KA, Chung SS, Noh GT.   +8 more
europepmc   +1 more source

Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming

iMeta, EarlyView.
The graphical abstract illustrates the molecular mechanism by which chondroitin sulfate (DCS) alleviates glucocorticoid‐induced myopathy through the gut–muscle axis. DCS selectively enriches L. johnsonii Z‐RW, enhancing bshA‐encoded BSH activity to promote bile acid deconjugation and reduce the sugar–bile acid ratio, thereby re‐establishing intestinal ...
Ruiyun Wu, Tao Wen, Nan Shang, Penghao Xie, Zhenyu Wang, Hang Li, Shaobo Li, Dequan Zhang   +7 more
wiley   +1 more source

Kinetic modeling of mant-ATP turnover to interpret the biochemically defined myosin SRX state. [PDF]

Biophys J
Ježek F, Han SJ, Vander Roest AS, Beard DA.   +3 more
europepmc   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

The cytoskeleton regulates cytoophidium dynamics in Drosophila ovaries. [PDF]

Cell Biosci
Liu XJ, Li YL, Pang SY, Liu JL, Dou K.
europepmc   +1 more source