Results 191 to 200 of about 94,421 (295)

Heart‐On‐a‐Chip with Integrated Ultrasoft Mechanosensors for Continuous Measurement of Cell‐ and Tissue‐Scale Contractile Stresses

Small, EarlyView.
We present a heart‐on‐a‐chip platform embedded with ultrasoft mechanosensors for real‐time, multi‐scale stress mapping in engineered cardiac tissues. The system enables simultaneous quantification of local cell‐generated stresses and global tissue contractile forces.
Ali Mousavi, Christina‐Marie Boghdady, Shihao Cui, Sabra Rostami, Amid Shakeri, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Milica Radisic, Christopher Moraes, Houman Savoji   +10 more
wiley   +1 more source

The coiled-coil domain of myosin-11 as a potential biomarker to detect patients with atherosclerotic cardiovascular disease risk. [PDF]

J Physiol Sci
Takahashi L, Tomiyama H, Kobori H, Hidaka Y, Orihara S, Uchida K, Satomi K, Taguri M, Chikamori T, Yokoyama U.   +9 more
europepmc   +1 more source

Evidence for Drop‐Like Nuclear Deformation in Sheared Endothelial Monolayers

Small, EarlyView.
Physiological shear stress smoothens endothelial monolayers by selectively eliminating less‐spread cells with tall, wrinkled nuclei. Nuclear volume and surface area remain constant, consistent with drop‐like deformation governed by geometric constraints.
Mohammad Mohajeri, Ting‐Ching Wang, Pooja Agarwal, Simran Kaur, Ankit Kumar, Richard B. Dickinson, Abhishek Jain, Tanmay P. Lele   +7 more
wiley   +1 more source

Restoring dendritic cell interstitial motility via PDE5 inhibition for sustained antitumor immunity. [PDF]

J Natl Cancer Cent
Zang R, Zhang C, Ding G, Zhang J.
europepmc   +1 more source

Leveraging Viscosity to Unlock the Osteogenic Potential of BMP‐2 Mimetic DWIVA

Small, EarlyView.
Dynamic interfaces based on supported lipid bilayers demonstrate that the osteogenic potential of the BMP‐2 mimetic DWIVA can be harnessed by modulating substrate viscosity. This work highlights that the viscous properties of the cellular microenvironment play a crucial role in the mechanosensitive regulation of growth factor activity.
Finlay Cunniffe, Ziyuan Luo, Eva Barcelona‐Estaje, Eva Forrest, Manuel Salmeron‐Sanchez, Marco Cantini   +5 more
wiley   +1 more source

Coexistence of Hypertrophic Cardiomyopathy and Arterial Hypertension: Current Insights and Future Directions. [PDF]

Diseases
Katsi V, Papadomarkaki K, Manousiadis K, Triantafyllou E, Fragoulis C, Tsioufis K.   +5 more
europepmc   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, EarlyView.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, EarlyView.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source

Comparing the Efficacy of Myosin Inhibition Versus Thin Filament Calcium Desensitization for Treatment of Pediatric Restrictive Cardiomyopathy Using a Patient-Derived hiPSC Model. [PDF]

Circ Genom Precis Med
Staudt DW, Serrano R, Hnatiuk AP, Sanchez I, Carhuamaca X, Feyen DAM, Mercola M.   +6 more
europepmc   +1 more source