Results 21 to 30 of about 1,503,695 (131)

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Myofibre Hyper-Contractility in Horses Expressing the Myosin Heavy Chain Myopathy Mutation, MYH1E321G [PDF]

, 2021
Myosinopathies are defined as a group of muscle disorders characterized by mutations in genes encoding myosin heavy chains. Their exact molecular and cellular mechanisms remain unclear.
Finno, Carrie J., Ochala, Julien; id_orcid, Valberg, Stephanie J, Julien Ochala, Valberg, Stephanie J., Ochala, Julien, Carrie J. Finno, Stephanie J. Valberg, Finno, Carrie J   +8 more
core   +1 more source

Uncovering cardiac molecular remodelling in racing Thoroughbreds with paroxysmal atrial fibrillation

Equine Veterinary Journal, EarlyView.
Abstract Background Atrial fibrillation (AF) is the most common arrhythmia in both humans and horses, with a comparable prevalence of ~2%. In horses, AF is a major cause of poor athletic performance and linked to sudden cardiac death, yet its underlying molecular mechanisms remain poorly understood.
Charlotte E. Edling, Magdalena Arevalo‐Turrubiarte, Carla Moller‐Levet, Bronte Forbes, Victoria Kemp, Joe Weir, Gary Tse, Celia Marr, Rebecca Lewis, Kamalan Jeevaratnam   +9 more
wiley   +1 more source

Symptomatic distal myopathy with cardiomyopathy due to a MYH7 mutation.

, 2007
Contains fulltext : 52264timmermans.pdf (Publisher’s version ) (Closed access)Mutations in the myosin heavy chain gene (MYH7) can cause several distinct phenotypes depending on the location of the mutation: hypertrophic cardiomyopathy ...
Grootscholten, M.I., Timmermans, J., Zwarts, M.J., Schelhaas, H.J., Wijngaard, A. van de, Blijham, P.J., Laak, H.J. ter, Overeem, S.   +7 more
core   +1 more source

TRIM32 controls timely cell cycle exit in muscular differentiation through downregulation of c‐Myc mRNA

The FEBS Journal, EarlyView.
Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong, Elisa Lazzari, Sabrina Pacor, Simeone Dal Monego, Erica Piovesan, Danilo Licastro, Germana Meroni   +6 more
wiley   +1 more source

Desmin is not ubiquitously expressed in head and neck muscle fibers

Journal of Anatomy, EarlyView.
Desmin is not ubiquitously expressed in human head and neck muscle fibers. A subset of fibers showed absent or very weak desmin immunoreactivity, with corresponding reduction or absence of desmin mRNA expression. Abstract Desmin, a major muscle‐specific intermediate filament protein, is widely regarded as a ubiquitous component of mature skeletal ...
Per Stål, Jingxia Liu, Fatima Pedrosa Domellöf, Farhan Shah   +3 more
wiley   +1 more source

Effects of myosin heavy chain (MHC) plasticity induced by HMGCoA-reductase inhibition on skeletal muscle functions. [PDF]

, 2011
The rate-limiting step of cholesterol biosynthetic pathway is catalyzed by 3-hydroxy-3-methylglutaryl coenzyme reductase (HGMR), whose inhibitors, the statins, widely used in clinical practice to treat hypercholesterolemia, often cause myopathy, and ...
Trapani, Laura, Moreno, Sandra, Swiezewska, Ewa, Campolongo, Patrizia, Melli, Luca, Linari, Marco, Jóźwiak, Adam, Fanelli, Francesca, Trezza, Viviana, Pallottini, Valentina, Segatto, Marco, Pucillo, Leopoldo Paolo   +11 more
core  

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Mitochondrial permeability transition in skeletal muscle phenocopies muscle alterations seen in cancer cachexia and other wasting conditions

The Journal of Physiology, EarlyView.
Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel, Cole Lukasiewicz, Sarah Skinner, Mark R. Viggars, Sung Gi Noh, Martin Picard, Abbey‐Gale Mannings, Michael S. Cohen, Dennis W. Wolan, Terence E. Ryan, Russell T. Hepple   +10 more
wiley   +1 more source

Myosin myopathy. A new disease entity

, 2003
By the discovery and characterization of two familial myopathies caused by mutations in myosin heavy chaingenes, we introduce a new entity within the field of neuromuscular disorders: Myosin myopathyThe first myopathy affected a family in western Sweden.
Tajsharghi, Homa 1968-
core   +2 more sources