Results 31 to 40 of about 1,503,695 (131)

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Rosa Sirica, Melania Murolo, Emery Di Cicco, Daniela Terracciano, Anna Pannaccione, Monica Dentice   +12 more
wiley   +1 more source

sj-pdf-1-vet-10.1177_03009858231204253 – Supplemental material for Myosin heavy-chain myopathy in 2 American quarter horses

, 2023
Supplemental material, sj-pdf-1-vet-10.1177_03009858231204253 for Myosin heavy-chain myopathy in 2 American quarter horses by Mayane Faccin, Kirsten A. Landsgaard, Sarai M. Milliron, Alexis H. Jennings, M. Keith Chaffin, Paula R.
Alexis H. Jennings (17133164), M. Keith Chaffin (572112), Paula R. Giaretta (4582285), Raquel R. Rech (4582282), Kirsten A. Landsgaard (17133158), Sarai M. Milliron (17133161), Mayane Faccin (16019903)   +6 more
core   +1 more source

Diabetic Polyneuropathy Patients Exhibit an Altered Skeletal Muscle Proteome Phenotype

PROTEOMICS – Clinical Applications, Volume 20, Issue 6, November 2026.
ABSTRACT Purpose Diabetic polyneuropathy (DPN) is a debilitating complication of diabetes that affects motor nerves and may impair skeletal muscle health. This study investigated skeletal muscle proteomic alterations associated with DPN compared with type 2 diabetes without DPN (T2D) and healthy controls (CON).
Frederik Forsberg Thybo, Karolina Snopek Khan, Jesper Emil Jakobsgaard, Henning Andersen, Kristian Vissing, Johan Palmfeldt   +5 more
wiley   +1 more source

Myosin VI Lever Arm Rotation: Fixed or Variable? [PDF]

, 2010
Two recent articles addressed the power-stroke of myosin VI molecules during stepping. Although both groups measured the angles of fluorescent probes attached on the myosin VI molecule lever arm using polarized fluorescence techniques, they differ about ...
Yujie Sun, Harry W. Schroeder III, Kazuaki Homma, John Beausang, Mitsuo Ikebe, Yale Goldman, John F. Beausang, Harry Schroeder III, Yale E. Goldman   +8 more
core   +1 more source

Embryonic myosin heavy-chain mutations cause distal arthrogryposis and developmental myosin myopathy that persists postnatally

, 2008
Background: Myosin is a molecular motor and the essential part of the thick filament of striated muscle. The expression of myosin heavy-chain (MyHC) isoforms is developmentally regulated.
Tajsharghi, Homa, Jerre, Ragnar, Kimber, Eva,, Kroksmark, Anna-Karin, Oldfors, Anders, Tulinius, Mar   +5 more
core   +2 more sources

Rev‐erb‐α in Skeletal Muscle Adaptation: Integrating Circadian Control Mechanisms and Exercise Dynamic Responses

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Circadian rhythms orchestrate a host of biological processes in a time‐dependent manner to maintain homeostasis in response to exercise. Within this framework, Rev‐erb‐α, an intracellular nuclear receptor and transcriptional regulator, transcends its role in circadian rhythms to drive myogenesis, muscle remodeling, primary metabolism, and ...
Ivo Vieira de Sousa Neto, Alisson Luiz da Rocha, Ana Paula Pinto, Eliézer Lucas Pires Ramos, Eduardo Rochete Ropelle, José Rodrigo Pauli, Ellen Cristini de Freitas, Adelino Sanchez Ramos da Silva   +7 more
wiley   +1 more source

Alternative Exon 9-Encoded Relay Domains Affect More than One Communication Pathway in the Drosophila Myosin Head [PDF]

, 2009
We investigated the biochemical and biophysical properties of one of the four alternative regions within the Drosophila myosin catalytic domain: the relay domain encoded by exon 9.
Girish C. Melkani, Bernstein, Sanford I., Corey M. Dambacher, Geeves, M., Melkani, Girish C., Knowles, Aileen F., Geeves, Michael A., Marieke J. Bloemink, Aileen F. Knowles, Melanki, G., Bloemink, Marieke J., Bloemink, M., Bernstein, S., Sanford I. Bernstein, Dambacher, C., Knowles, A., Dambacher, Corey M., Michael A. Geeves   +17 more
core   +1 more source

Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Yves Henrotin, Antoine Florin, Christelle Sanchez, Prescilia Centonze, Tiago Pinto Coelho, Sophie Bekisz, Jean‐Emile Dubuc, Olivier Galand, Cécile Lambert   +8 more
wiley   +1 more source

Slow myosin heavy chain isozyme in nemaline myopathy.

, 1985
Muscle biopsies from two sporadic cases of congenital nemaline myopathy were examined for myosin heavy chain composition. Electrophoresis of congenital nemaline myopathy (CNM) muscle myosin in SDS-5% polyacrylamide gels gave rise to a single heavy chain ...
Scarpini E, DAMIANI, ERNESTO, MARGRETH, ALFREDO, Biral D, Scarlato G.   +4 more
core   +1 more source

Modulating Myosin Restores Muscle Function in a Mouse Model of Nemaline Myopathy [PDF]

, 2016
Objective: Nemaline myopathy, one of the most common congenital myopathies, is associated with mutations in various genes including ACTA1. This disease is also characterized by various forms/degrees of muscle weakness, with most cases being severe and ...
Johan Lindqvist, Levy, Y, Hardeman, Edna C., Levy, Yotam, Paul Gregorevic, Hardeman, EC, Ochala, Julien; id_orcid, Lindqvist, J, Ochala, J, Pati-Alam, A, Gregorevic, Paul, Yotam Levy, Gregorevic, P, Edna C. Hardeman, Julien Ochala, Hardeman, EC ; https://orcid.org/, Ochala, Julien, Alisha Pati‐Alam, Pati-Alam, Alisha, Lindqvist, Johan, Levy, Yotam,, Gregorevic, Paul,, Lindqvist, Johan,, Hardeman, Edna C.,, Ochala, Julien,, Pati-Alam, Alisha,   +25 more
core   +1 more source