Results 41 to 50 of about 1,503,695 (131)

Integrated Single‐Myofibre Multi‐Omics Correlates Inflammatory State to Myosin Energetics in ICU‐Acquired Weakness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Skeletal muscle atrophy is a pervasive complication of critical illness that worsens survival and recovery, yet remains poorly explained by current clinical or molecular markers. Methods To directly connect disease‐associated molecular states to the contractile machinery, this study combined sequential functional, transcriptomic and
Alexandra M. Winant, Roger Moreno‐Justicia, Lucia Paolini, Wout J. Claassen, Coen A. C. Ottenheijm, Atul S. Deshmukh, Stefano Cattaneo, Simone Piva, Nicola Latronico, Robert A. E. Seaborne, Julien Ochala   +10 more
wiley   +1 more source

Myosin inhibition partially rescues the myofiber proteome in X-linked myotubular myopathy [PDF]

X-linked myotubular myopathy (XLMTM) due to MTM1 mutations is a rare and often lethal congenital myopathy. Its downstream molecular and cellular mechanisms are currently incompletely understood.
Ochala, Julien; id_orcid, Laitila, Jenni, Rostedt, Fanny, Zanoteli, Edmar, Lawlor, Michael W., Wallgren-Pettersson, Carina, Saito, Yoshihiko, Gineste, Charlotte, Nishino, Ichizo, Dugdale, Hannah F., Seaborne, Robert Ae, Jungbluth, Heinz; id_orcid, Seaborne, Robert A. E., Mack, David L., Gerlach Melhedegaard, Elise, Laporte, Jocelyn, Hessel, Anthony L., Ochala, Julien, Jungbluth, Heinz, Belhac, Vladimir, Seaborne, Robert A.E., Seaborne, Robert A. E.; id_orcid   +21 more
core   +2 more sources

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Hereditary myosin myopathies

, 2007
Hereditary myosin myopathies have emerged as a new group of muscle diseases with highly variable clinical features and onset during fetal development, childhood or adulthood. They are caused by mutations in skeletal muscle myosin heavy chain (MyHC) genes.
Oldfors, Anders,
core   +1 more source

High‐Protein Diet Ameliorates Cardiomyopathy in a Cardiac‐Specific AGL Knockout Mouse Model: Association With Upregulated Hepatic Gluconeogenesis

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Glycogen storage disease type IIIa (GSDIIIa) causes progressive cardiomyopathy, and current high‐fat dietary strategies lack consensus regarding long‐term cardiovascular safety. We evaluated the efficacy and safety of high‐protein versus high‐fat diets in a novel cardiac‐specific AGL knockout (CKO; AGLflox/flox/MHC‐Cre) mouse model to ...
Caiqi Du, Hao Fu, Tingting Yu, Sisi Cao, Haotian Zhang, Boda Wei, Cai Zhang, Juan Ye, Wenjun Long, Xiaoping Luo, Yan Liang   +10 more
wiley   +1 more source

Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3 [PDF]

, 2007
Maintenance of skeletal and cardiac muscle structure and function requires precise control of the synthesis, assembly, and turnover of contractile proteins of the sarcomere.
Kim, M.S., Spencer, J.A., Olson, E.N., Richardson, J.A., Shelton, J.M., Glass, D.J., Bassel-Duby, R., Fielitz, J., Latif, S.   +8 more
core   +1 more source

Piperine disrupts the OFF state of the resting thick filament of rat skeletal muscle, enhancing dynamic contractility in a fibre‐type‐dependent manner

The Journal of Physiology, Volume 604, Issue 18, Page 7739-7771, 15 September 2026.
Abstract figure legend We investigated the effects of piperine on (1) the structure of the resting thick filament and (2) dynamic contractility in fibres and intact slow (soleus) and fast (extensor digitorum longus, EDL) rat muscles, respectively. The structure of the resting thick filament was assessed pre‐ and post‐piperine incubation using small ...
Daniel Z. Kruse, Jon Herskind, Michel N. Kuehn, Annika J. Klotz, Anthony L. Hessel, Kristian Overgaard   +5 more
wiley   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK Pathways

Arthritis &Rheumatology, Volume 78, Issue 7, Page 1535-1553, July 2026.
Objective Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Additional file 2: of A novel missense mutation in the MYH7 gene causes an uncharacteristic phenotype of myosin storage myopathy: a case report

, 2019
Figure S1. Filtering process using Genomatix GeneGrid and Qiagen Ingenuity Variant Analysisâ ˘ software. (DOCX 42 kb)
Mamelona, Jean, Filice, Louisa, Oussedik, Youcef, Crapoulet, Nicolas, Ouellette, Rodney, Marrero, Alier   +5 more
openaire   +1 more source