Results 21 to 30 of about 15,582 (230)

MRI biomarker assessment of neuromuscular disease progression: a prospective observational cohort study [PDF]

, 2015
BACKGROUND: A substantial impediment to progress in trials of new therapies in neuromuscular disorders is the absence of responsive outcome measures that correlate with patient functional deficits and are sensitive to early disease processes ...
Fischmann, A, Hanna, MG, Machado, PM, Morrow, JM, Reilly, MM, Sinclair, CD, Thornton, JS, Yousry, TA   +7 more
core   +1 more source

The effects of an intronic polymorphism in TOMM40 and APOE genotypes in sporadic inclusion body myositis. [PDF]

, 2015
A previous study showed that, in carriers of the apolipoprotein E (APOE) genotype ε3/ε3 or ε3/ε4, the presence of a very long (VL) polyT repeat allele in "translocase of outer mitochondrial membrane 40" (TOMM40) was less frequent in patients with ...
Barohn, R.J., Bettencourt, C., Brady, S., De Bleecker, J., De Paepe, B., Dimachkie, M.M., Fox, Z., Gang, Q., Hanna, M.G., Healy, E., Hilton-Jones, D., Holton, J.L., Houlden, H., Machado, P.M., Mantegazza, R., Mastaglia, F., Moggio, M., Mora, M., Needham, M., Parton, M., Ripolone, M., Shaibani, A., Shieh, P.B., Violano, R., Zanoteli, E., Zanotti, S.   +25 more
core   +1 more source

Pembrolizumab on pre-existing inclusion body myositis: a case report

BMC Rheumatology, 2020
Background Cases of exacerbation of pre-existing neuromuscular diseases induced by immune checkpoint inhibitors (ICIs) have rarely been reported because patients with autoimmune diseases have generally been excluded from ICI therapy due to the increased ...
Naohiro Uchio, Atsushi Unuma, Toshiyuki Kakumoto, Masao Osaki, Yoshitaka Zenke, Kenichi Sakuta, Akatsuki Kubota, Yoshikazu Uesaka, Tatsushi Toda, Jun Shimizu   +9 more
doaj   +1 more source

Phenotypical statin‐associated immune‐mediated necrotizing myositis with histological features of inclusion body myositis

Rheumatology & Autoimmunity, 2023
Introduction Statin‐associated immune‐mediated necrotizing myositis (IMNM) is a rare but distinct idiopathic inflammatory myopathy (IIM) that requires early recognition and intervention to prevent irreversible muscle damage. It is typically characterized
Nicole Daver, Sara Tonini
doaj   +1 more source

Inclusion body myositis: Update on the diagnostic and therapeutic landscape

Frontiers in Neurology, 2022
Inclusion body myositis (IBM) is a progressive muscle disease affecting patients over the age of 40, with distinctive clinical and histopathological features. The typical clinical phenotype is characterized by prominent involvement of deep finger flexors
Elie Naddaf
doaj   +1 more source

A national registry for juvenile dermatomyositis and other paediatric idiopathic inflammatory myopathies: 10 years' experience; the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies [PDF]

, 2011
Objectives: The paediatric idiopathic inflammatory myopathies (IIMs) are a group of rare chronic inflammatory disorders of childhood, affecting muscle, skin and other organs.
Bohan, Bohan, Brown, Chinoy, Chinoy, Christen-Zaech, Clarissa A. Pilkington, Constantin, Elst, Gunawardena, Gunawardena, Huber, Huber, Huber, Huber, Isenberg, Joyce E. Davidson, Kevin Murray, Kim, Li, Li, Lovell, Lowry, Lucy R. Wedderburn, Maillard, Maillard, Marhaug, McCann, McCann, McCann, Mendez, Miller, Neil Martin, Pachman, Pachman, Petra Krol, Ravelli, Rider, Rider, Rider, Rider, Riley, Riley, Sally Smith, Salomonsson, Stringer, Symmons, Varsani, Wedderburn, Wedderburn, Wedderburn   +50 more
core   +1 more source

A recipe for myositis : nuclear factor κB and nuclear factor of activated T-cells transcription factor pathways spiced up by cytokines [PDF]

, 2017
Nuclear factor κB (NF-κB) is a well-known pro-inflammatory transcription factor that regulates the expression of the tissue’s immune-active components, which include cytokines, chemokines and adhesion molecules.
De Paepe, Boel
core   +3 more sources

Polymyositis and dermatomyositis: Disease spectrum and classification

Indian Journal of Dermatology, 2012
Muscle inflammation and weakness are the key features of idiopathic inflammatory myopathies (IIMs). In addition IIMs are frequently associated with cutaneous and pulmonary involvement. In clinical practice the three common inflammatory myopathies we come
Siba P Raychaudhuri, Anupam Mitra
doaj   +1 more source

Sarcoidosis presenting as granulomatous myositis in a 16-year-old adolescent [PDF]

, 2016
BACKGROUND: Sarcoidosis is a multi-system disease characterized by the presence of non-caseating epithelioid granulomas in affected tissues, including skeletal muscle.
Eutsler, Eric Eutsler, Ferguson, Cole, Kitcharoensakkul, Maleewan, Orandi, Amir B, White, Andrew J   +4 more
core   +2 more sources

Inclusion-Body Myositis Associated with Alzheimer’s Disease

Case Reports in Medicine, 2013
Sporadic inclusion-body myositis (s-IBM) is a myopathy that is characterized by progressive weakness and muscle pathology demonstrating inflammation and rimmed vacuoles.
Danijela Levacic, Leema Reddy Peddareddygari, David Nochlin, Leroy R. Sharer, Raji P. Grewal   +4 more
doaj   +1 more source