Results 131 to 140 of about 62,398 (280)

Clinical Safety of Extended Interval Dosing of Nivolumab in Patients with Melanoma

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 997-1004, April 2026.
Extended interval dosing regimens of immune checkpoint inhibitors have been implemented widely. However, their approval was mainly based on pharmacokinetic modeling and simulations. Consequently, comparative safety data of extended interval dosing regimens in a real‐world setting are limited.
Ruben Malmberg, Maaike M. Hofman, Fatima Ashad, Alaa Daloul, Stefani Oosterveld, Edwin A. Basak, Esther Oomen‐de Hoop, Astrid A. M. van der Veldt, Arjen Joosse, Roelof W. F. van Leeuwen, Ron H. J. Mathijssen   +10 more
wiley   +1 more source

Associations between adjustment disorder and hospital-based infections in the Danish population. [PDF]

, 2020
OBJECTIVE:There is some evidence that posttraumatic stress disorder (PTSD) is associated with increased risk of infections, and it is unknown whether adjustment disorder is as well.
Farkas, Dóra Körmendiné, Galea, Sandro, Gradus, Jaimie L, Jiang, Tammy, Lash, Timothy L, Smith, Meghan L, Sumner, Jennifer A, Sørensen, Henrik Toft   +7 more
core  

Major Basic Protein Deposition Without Eosinophilic Infiltration in Hypercontractile Esophagus: A Case Report

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Hypercontractile esophagus is a motility disorder characterized by excessive contractions in the esophageal body. Certain cases of hypercontractile esophagus exhibit eosinophilic infiltration in the muscle layer; however, its clinical significance is unclear.
Tetsuya Tatsuta, Keinosuke Hizuka, Shigeharu Ueki, Masatoshi Kaizuka, Shinji Oota, Keisuke Hasui, Hidezumi Kikuchi, Hiroto Hiraga, Daisuke Chinda, Hirotake Sakuraba   +9 more
wiley   +1 more source

MYOSITIS [PDF]

Journal of the American Medical Association, 1914
In 1869 Volkmann described a contracted condition of the flexor muscles of the wrist, hand and fingers which he termed an ischemic paralysis, but which came to be known clinically as Volkmann's contracture. He believed at that time that the condition was due to a death of the muscle cells consequent on a prolonged deprivation of the blood from the part,
openaire   +1 more source

Evaluation of Dysphagia in Myositis and Muscular Dystrophy Using Real‐Time MRI and Quantitative Muscle Ultrasound

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Swallowing dysfunction—dysphagia—is a frequent and debilitating symptom in neuromuscular disorders, leading to malnutrition, cachexia, aspiration pneumonia, and death. Identification of the underlying pathophysiological mechanisms is important for diagnosis and treatment.
Rachel Zeng, Anke Rietveld, Omar Al‐Bourini, Rosemarie H. M. J. M. Kroon, Arno Olthoff, Matthias Weidenmüller, Per‐Ole Carstens, Isabel Kommerell, Saskia G. Schütz, Corinne G. C. Horlings, Johanna G. Kalf, Bert J. M. de Swart, Baziel G. M. van Engelen, Tim Friede, Sabine Hofer, Jens Frahm, Ali Seif Amir Hosseini, Jens Schmidt, Christiaan G. J. Saris   +18 more
wiley   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Results and Exploratory Biomarker Analyses of a Phase II Study CHANGEABLE: Combination of PD‐1 Inhibitor and Niraparib in GErm‐Line‐mutAted Metastatic Breast Cancer

MedComm, Volume 7, Issue 4, April 2026.
This phase II trial evaluated the efficacy and safety of niraparib combined with HX008 in metastatic breast cancer (MBC) patients with germline DNA damage response (DDR) gene mutations. This chemotherapy‐free regimen demonstrates promising efficacy and a tolerable safety profile in MBC patients with germline DDR mutations, providing a novel therapeutic
Jian Zhang, Yiqun Du, Yanchun Meng, Yizi Jin, Mingxi Lin, Xuchen Shao, Xiaojun Liu, Yuxin Mu, Yun Liu, Zhen Hu   +9 more
wiley   +1 more source

Acquired trigemino‐abducens synkinesis in a dog with immune‐mediated masticatory myositis

Journal of Small Animal Practice, EarlyView.
S. Garzón, T. Liatis
wiley   +1 more source

Impact of Pharmacokinetic Gene Polymorphisms on Statin‐Induced Myotoxicity in Thai Patients Treated With Simvastatin

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Statin‐induced myotoxicity (SIM) is a common adverse effect of simvastatin therapy, which can negatively impact patient adherence and treatment outcomes. This study aims to investigate the impacts of pharmacokinetic (PK) gene polymorphisms on SIM in Thai population treated with simvastatin.
Sayanit Tipnoppanon, Sarawut Siwamogsatham, Yongkasem Vorasettakarnkij, Chonlaphat Sukasem, Pajaree Chariyavilaskul, Patompong Satapornpong, Natchaya Vanwong   +6 more
wiley   +1 more source

Nailfold capillaroscopy in myositis: A case series

SAGE Open Medical Case Reports
Nailfold capillaroscopy is well established in systemic sclerosis; however, abnormalities (scleroderma or scleroderma-like patterns) are identified in other connective tissue diseases, such as myositis, even in the absence of Raynaud’s phenomenon ...
Thaisa Cotton, Marie Hudson, Yves Troyanov, Valérie Leclair, Geneviève Gyger   +4 more
doaj   +1 more source