Results 191 to 200 of about 26,633 (217)

State-of-the-art insights into myokines as biomarkers of sarcopenia: a literature review. [PDF]

Int J Physiol Pathophysiol Pharmacol
Moussaoui OR, Deligiannis I, Petrov PP, Velikova T, Assyov Y.   +4 more
europepmc   +1 more source

Pharmacological inhibition of myostatin effectively ameliorates osteolytic lesions in syngeneic and xenograft breast cancer mouse models. [PDF]

Oncogene
Reinhardt J, Dankbar B, Geers F, Werbenko E, Geyer C, Bleckmann A, Menck K, Grözinger A, Hartmann W, Tio J, Höltke C, Helfen A, Lodberg A, Al-Qasemi R, Beckmann D, Bödecker S, Kleimann S, Wessendorf L, Wawersig D, Pap T, Wehmeyer C.   +20 more
europepmc   +1 more source

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siRNAs targeting mouse myostatin

Biochemistry (Moscow), 2008
Eight different mouse myostatin small interfering RNA (siRNAs) were synthesized and tested. Five siRNAs showed a pronounced biological effect reducing myostatin mRNA content. For two of them, the myostatin mRNA level was reduced 3- and 4-fold, respectively.
V A, Furalyov, I V, Kravchenko, V P, Khotchenkov, V O, Popov   +3 more
openaire   +2 more sources

Myostatin and carbohydrate disturbances

Endocrine Research, 2016
Purpose/aim of the study: Myostatin is a myokine that has been shown to inhibit muscle growth and to have potentially deleterious effects on metabolism. The aim of the current study was to compare its circulating serum levels in subjects from the whole spectrum of carbohydrate disturbances leading to diabetes.A total of 159 age-, sex-, and BMI-matched ...
Yavor S, Assyov, Tsvetelina V, Velikova, Zdravko A, Kamenov   +2 more
openaire   +2 more sources

Myostatin: Biology and Clinical Relevance

Mini-Reviews in Medicinal Chemistry, 2006
Myostatin is a negative regulator of muscle mass. Important advances in our understanding of the complex biology of this factor have revealed the therapeutic potential of antagonizing the myostatin pathway. Here we present the rationale for evaluating anti-myostatin therapies in human muscle-wasting disorders.
Carnac, Gilles, Ricaud, Stéphanie, Vernus, Barbara, Bonnieu, Anne   +3 more
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Role of myostatin in metabolism

Current Opinion in Clinical Nutrition & Metabolic Care, 2004
To review papers on myostatin published in 2003 and early 2004. Myostatin is a negative regulator of skeletal muscle mass produced in this tissue. Inactivating mutations of the myostatin gene or interaction of myostatin protein with follistatin and other inhibitory proteins induce a hypermuscular phenotype in cattle and mice; this is assumed to result ...
Nestor F, Gonzalez-Cadavid, Shalender, Bhasin   +1 more
openaire   +2 more sources

Myostatin: Basic biology to clinical application

2022
Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed by animal and human skeletal muscle cells where it limits muscle growth and promotes protein breakdown. Its effects are influenced by complex mechanisms including transcriptional and epigenetic regulation and modulation by extracellular binding proteins. Due to
Esposito P., Picciotto D., Battaglia Y., Costigliolo F., Viazzi F., Verzola D.   +5 more
openaire   +2 more sources

Identification of the Minimum Peptide from Mouse Myostatin Prodomain for Human Myostatin Inhibition

Journal of Medicinal Chemistry, 2015
Myostatin, an endogenous negative regulator of skeletal muscle mass, is a therapeutic target for muscle atrophic disorders. Here, we identified minimum peptides 2 and 7 to effectively inhibit myostatin activity, which consist of 24 and 23 amino acids, respectively, derived from mouse myostatin prodomain. These peptides, which had the propensity to form
Kentaro, Takayama, Yuri, Noguchi, Shin, Aoki, Shota, Takayama, Momoko, Yoshida, Tomo, Asari, Fumika, Yakushiji, Shin-ichiro, Nishimatsu, Yutaka, Ohsawa, Fumiko, Itoh, Yoichi, Negishi, Yoshihide, Sunada, Yoshio, Hayashi   +12 more
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Myostatin expression during human muscle hypertrophy and subsequent atrophy: increased myostatin with detraining

Scandinavian Journal of Medicine & Science in Sports, 2011
Myostatin is a potent negative regulator of skeletal muscle mass, but its role in human skeletal muscle hypertrophy and atrophy is sparsely described. Muscle biopsies were obtained from young male subjects before and after 30 and 90 days of resistance training as well as after 3, 10, 30, 60 and 90 days of subsequent detraining. Myostatin mRNA increased
J G, Jespersen, A, Nedergaard, L L, Andersen, P, Schjerling, J L, Andersen   +4 more
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Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise

Clinical and Experimental Pharmacology and Physiology, 2012
Summary Myostatin (MSTN) has been implicated in metabolic adaptation to physiological stimuli, such as physical exercise, which is linked to improved glucose homeostasis. The aim of the present study was to evaluate the influence of exercise on the expression of MSTN, MSTN receptors (ActRIIB and ALK4) and follistatin (FS) in the muscle and fat of ...
Daniela B, Dutra, Patrícia G, Bueno, Rafaella N, Silva, Natália H, Nakahara, Heloísa S, Selistre-Araújo, Keico O, Nonaka, Angela Mo, Leal   +6 more
openaire   +2 more sources