Results 171 to 180 of about 19,108 (217)
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Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise
Clinical and Experimental Pharmacology and Physiology, 2012Summary Myostatin (MSTN) has been implicated in metabolic adaptation to physiological stimuli, such as physical exercise, which is linked to improved glucose homeostasis. The aim of the present study was to evaluate the influence of exercise on the expression of MSTN, MSTN receptors (ActRIIB and ALK4) and follistatin (FS) in the muscle and fat of ...
Daniela B, Dutra +6 more
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Myostatin in Muscle Growth and Repair
Exercise and Sport Sciences Reviews, 2001Myostatin, a member of the TGF beta superfamily, regulates skeletal muscle size by controlling embryonic myoblast proliferation. Recent results show that myostatin may also have a role in muscle regeneration and muscle wasting of adult animals. This review summarizes the recent developments in the regulation of myostatin gene expression and mechanism ...
M, Sharma +3 more
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Myostatin is an inhibitor of myogenic differentiation
American Journal of Physiology-Cell Physiology, 2002Myostatin (MSTN), a transforming growth factor (TGF)-β superfamily member, has been shown to negatively regulate muscle growth by inhibiting muscle precursor cell proliferation. Here, we stably transfected C2C12 cells with mouse MSTN cDNA to investigate its possible role in myoblast differentiation.
Ramón, Ríos +3 more
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siRNAs targeting mouse myostatin
Biochemistry (Moscow), 2008Eight different mouse myostatin small interfering RNA (siRNAs) were synthesized and tested. Five siRNAs showed a pronounced biological effect reducing myostatin mRNA content. For two of them, the myostatin mRNA level was reduced 3- and 4-fold, respectively.
V A, Furalyov +3 more
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Identification of the Minimum Peptide from Mouse Myostatin Prodomain for Human Myostatin Inhibition
Journal of Medicinal Chemistry, 2015Myostatin, an endogenous negative regulator of skeletal muscle mass, is a therapeutic target for muscle atrophic disorders. Here, we identified minimum peptides 2 and 7 to effectively inhibit myostatin activity, which consist of 24 and 23 amino acids, respectively, derived from mouse myostatin prodomain. These peptides, which had the propensity to form
Kentaro, Takayama +12 more
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REGULATION OF MUSCLE MASS BY MYOSTATIN
Annual Review of Cell and Developmental Biology, 2004▪ Abstract Myostatin is a secreted protein that acts as a negative regulator of skeletal muscle mass. During embryogenesis, myostatin is expressed by cells in the myotome and in developing skeletal muscle and acts to regulate the final number of muscle fibers that are formed.
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Myostatin: An Overlooked Player in Heart Failure?
European Journal of Heart Failure, 2010Sillje, Herman H. W., de Boer, Rudolf A.
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