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Follistatin Complexes Myostatin and Antagonises Myostatin-Mediated Inhibition of Myogenesis
Developmental Biology, 2004 Follistatin is known to antagonise the function of several members of the TGF-beta family of secreted signalling factors, including Myostatin, the most powerful inhibitor of muscle growth characterised to date. In this study, we compare the expression of Myostatin and Follistatin during chick development and show that they are expressed in the vicinity
Ketan Patel, Helge Amthor, Ravi Kambadur
exaly +4 more sources
Myostatin: Expanding Horizons [PDF]
IUBMB Life, 2015 AbstractMyostatin is a secreted growth and differentiation factor that belongs to the TGF‐β superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels ...
Himani Kukreti +2 more
exaly +5 more sources
Latent Myostatin Has Significant Activity and This Activity Is Controlled More Efficiently by WFIKKN1 Than by WFIKKN2 [PDF]
FEBS Journal, 2013 Myostatin, a negative regulator of skeletal muscle growth, is produced from myostatin precursor by multiple steps of proteolytic processing. After cleavage by a furin-type protease, the propeptide and growth factor domains remain associated, forming a
Laszlo Patthy +2 more
exaly +2 more sources
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Role of myostatin in metabolism
Current Opinion in Clinical Nutrition & Metabolic Care, 2004To review papers on myostatin published in 2003 and early 2004. Myostatin is a negative regulator of skeletal muscle mass produced in this tissue. Inactivating mutations of the myostatin gene or interaction of myostatin protein with follistatin and other inhibitory proteins induce a hypermuscular phenotype in cattle and mice; this is assumed to result ...
Nestor F, Gonzalez-Cadavid +1 more
openaire +2 more sources
Myostatin and carbohydrate disturbances
Endocrine Research, 2016Purpose/aim of the study: Myostatin is a myokine that has been shown to inhibit muscle growth and to have potentially deleterious effects on metabolism. The aim of the current study was to compare its circulating serum levels in subjects from the whole spectrum of carbohydrate disturbances leading to diabetes.A total of 159 age-, sex-, and BMI-matched ...
Yavor S, Assyov +2 more
openaire +2 more sources