Results 141 to 150 of about 12,955 (195)
Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies
Frontiers in Physiology, 2022 Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has made it an important therapeutic target.
Mohd Hassan Baig +2 more
exaly +5 more sources
Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis
Developmental Biology, 2004 Follistatin is known to antagonise the function of several members of the TGF-beta family of secreted signalling factors, including Myostatin, the most powerful inhibitor of muscle growth characterised to date. In this study, we compare the expression of Myostatin and Follistatin during chick development and show that they are expressed in the vicinity
Ketan Patel +2 more
exaly +4 more sources
Myostatin: Expanding horizons [PDF]
IUBMB Life, 2015 AbstractMyostatin is a secreted growth and differentiation factor that belongs to the TGF‐β superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels ...
Himani Kukreti, Craig Mcfarlane
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Role of myostatin in metabolism
Current Opinion in Clinical Nutrition & Metabolic Care, 2004To review papers on myostatin published in 2003 and early 2004. Myostatin is a negative regulator of skeletal muscle mass produced in this tissue. Inactivating mutations of the myostatin gene or interaction of myostatin protein with follistatin and other inhibitory proteins induce a hypermuscular phenotype in cattle and mice; this is assumed to result ...
Nestor F, Gonzalez-Cadavid +1 more
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Myostatin and carbohydrate disturbances
Endocrine Research, 2016Purpose/aim of the study: Myostatin is a myokine that has been shown to inhibit muscle growth and to have potentially deleterious effects on metabolism. The aim of the current study was to compare its circulating serum levels in subjects from the whole spectrum of carbohydrate disturbances leading to diabetes.A total of 159 age-, sex-, and BMI-matched ...
Yavor S, Assyov +2 more
openaire +2 more sources
Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise
Clinical and Experimental Pharmacology and Physiology, 2012Summary Myostatin (MSTN) has been implicated in metabolic adaptation to physiological stimuli, such as physical exercise, which is linked to improved glucose homeostasis. The aim of the present study was to evaluate the influence of exercise on the expression of MSTN, MSTN receptors (ActRIIB and ALK4) and follistatin (FS) in the muscle and fat of ...
Daniela B, Dutra +6 more
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Myostatin in Muscle Growth and Repair
Exercise and Sport Sciences Reviews, 2001Myostatin, a member of the TGF beta superfamily, regulates skeletal muscle size by controlling embryonic myoblast proliferation. Recent results show that myostatin may also have a role in muscle regeneration and muscle wasting of adult animals. This review summarizes the recent developments in the regulation of myostatin gene expression and mechanism ...
M, Sharma +3 more
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Myostatin is an inhibitor of myogenic differentiation
American Journal of Physiology-Cell Physiology, 2002Myostatin (MSTN), a transforming growth factor (TGF)-β superfamily member, has been shown to negatively regulate muscle growth by inhibiting muscle precursor cell proliferation. Here, we stably transfected C2C12 cells with mouse MSTN cDNA to investigate its possible role in myoblast differentiation.
Ramón, Ríos +3 more
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siRNAs targeting mouse myostatin
Biochemistry (Moscow), 2008Eight different mouse myostatin small interfering RNA (siRNAs) were synthesized and tested. Five siRNAs showed a pronounced biological effect reducing myostatin mRNA content. For two of them, the myostatin mRNA level was reduced 3- and 4-fold, respectively.
V A, Furalyov +3 more
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