Results 141 to 150 of about 2,019 (200)

Randomized Phase 3 Comparison of a 2-Dose and 3-Dose Regimen of a Detoxified Toxin A/B <i>Clostridioides difficile</i> Vaccine in Adults 50 Years and Older. [PDF]

Open Forum Infect Dis
Crook G, Lamberth E, Lockhart SP, Lowry F, Zhang H, Peng Y, Koury K, Kalina WV, Pride MW, Anderson AS, Gruber WC, Kitchin N.   +11 more
europepmc   +1 more source

An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in atherosclerosis. [PDF]

Front Cell Dev Biol
Guo J, Du L.
europepmc   +1 more source

A longitudinal analysis of Clostridioides difficile virulence profiles across three geographic regions in Israel (2020-2022). [PDF]

Ann Clin Microbiol Antimicrob
Schwartz O, Peretz A, Azrad M.
europepmc   +1 more source

Muscle atrophy after ACL reconstruction involves molecular mechanisms beyond unloading. [PDF]

J Appl Physiol (1985)
Keeble AR, Gonzalez-Velez S, Thomas NT, Owen AM, Stone AV, Johnson DL, Candia J, Ferrucci L, Narici M, Dupont-Versteegden EE, Noehren B, Franchi MV, Fry CS.   +12 more
europepmc   +1 more source

Venomous Peptides: Molecular Origin of the Toxicity of Snake Venom PLA₂-like Peptides. [PDF]

JACS Au
Coimbra JTS, Gissler A, Nitor E, Rostamipour K, Cunha AV, Ramos MJ, Fernandes PA.   +6 more
europepmc   +1 more source

Localization of Myotoxin I and Myotoxin II From the Venom of Bothrops Asper in a Murine Model

Toxicon, 2021
Phospholipases A2 (PLA2s) and PLA2-like proteins are significant components of snake venoms. Some of these proteins act as potent toxins causing muscle necrosis, which may lead to amputation in severe envenomings. Fundamental aspects of the mechanism of action of these toxins are still not completely known.
Fiorella Tonello, Julián Fernández, Bruno Lomonte   +2 more
exaly   +6 more sources

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Structural, Biological and Biochemical Studies of MyotoxinaAnd Homologous Myotoxins

Journal of Toxicology: Toxin Reviews, 1997
AbstractMyotoxin a and a group of closely related, small, basic toxins cause myonecrotic destruction of muscle tissue upon envenomation. The sarcoplasmic reticulum swells and eventually breaks down to small vesicles. Degeneration of myofibrils and myofilaments ensues and loss of the classic striation pattern is apparent.
A. L. Bieber, D. Nedelkov
openaire   +1 more source

Binding of myotoxin a to cultured muscle cells

Toxicon, 1993
The binding of radiolabeled myotoxin a to various cultured cell lines was evaluated. One rat skeletal muscle-derived cell line, L8, bound substantially more myotoxin a than did all all other cell lines examined. Several biophysical parameters of myotoxin a-L8 binding were determined. Binding was saturable with a moderate binding affinity.
B, Baker, A T, Tu, J L, Middlebrook
openaire   +2 more sources

Purification and Characterization of Myotoxin IV, a Phospholipase A2 Variant, From Bothrops Asper Snake Venom

Natural Toxins, 1995
A basic myotoxic protein was purified from Bothrops asper venom. Like other basic Bothrops myotoxins, myotoxin IV induces acute muscle damage after intramuscular injection in mice and disrupts negatively charged liposomes but not positively charged ones.
Cecilia Diaz, José María Gutiérrez, Bruno Lomonte   +2 more
exaly   +2 more sources

Similarities and differences in mechanisms of cardiotoxins, melittin and other myotoxins

Toxicon, 1996
Myonecrosis induced in vivo by cardiotoxin, melittin, and Asp49 and Lys49 phospholipase A2 (PLA2) myotoxins involves rapid lysis of the sarcolemma, myofibril clumping, and hypercontraction of sarcomeres. In contrast, skeletal muscle necrosis induced by crotamine and myotoxin a is much slower, consisting of mitochondrial and sarcoplasmic reticulum ...
J E, Fletcher, M, Hubert, S J, Wieland, Q H, Gong, M S, Jiang   +4 more
openaire   +2 more sources