Results 151 to 160 of about 2,019 (200)
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Journal of Molecular Medicine, 2021
Crotamine is a rattlesnake-derived toxin that causes fast-twitch muscle paralysis. As a cell-penetrating polypeptide, crotamine has been investigated as an experimental anti-cancer and immunotherapeutic agent. We hypothesized that molecules targeting crotamine could be designed to study its function and intervene in its adverse activities.
Celine Pompeia +8 more
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Crotamine is a rattlesnake-derived toxin that causes fast-twitch muscle paralysis. As a cell-penetrating polypeptide, crotamine has been investigated as an experimental anti-cancer and immunotherapeutic agent. We hypothesized that molecules targeting crotamine could be designed to study its function and intervene in its adverse activities.
Celine Pompeia +8 more
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Effects of myotoxins on skeletal muscle fibers
Progress in Neurobiology, 1995This review highlights various aspects of a number of experimental myological alterations, induced by different chemical toxicants, including anticholinesterase, colchicine, vincristine, chloroquine, tetanus toxin, botulinum toxin, reserpine and emetine.
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Structure-function relationship of myotoxin a using peptide fragments
Archives of Biochemistry and Biophysics, 1992Myotoxin a, a small basic polypeptide isolated from the venom of prairie rattlesnake (Crotalus viridis viridis), has been shown to bind to sarcoplasmic reticulum (SR) Ca(2+)-ATPase. The attachment of myotoxin a to Ca(2+)-ATPase is believed to cause uncoupling of the calcium pump.
B, Baker, P, Utaisincharoen, A T, Tu
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Interaction of myotoxin with a artificial membranes: Raman spectroscopic investigations
Biochemistry, 1985Myotoxin a from the venom of Crotalus viridis viridis (prairie rattlesnake) is a small protein which is responsible for myonecrosis. It is a basic protein with 42 amino acid residues of known sequence. Three disulfide bonds give it a highly compact structure.
W K, Liddle, A T, Tu
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Purification and properties of a myotoxin from Conus geographus venom
Archives of Biochemistry and Biophysics, 1978Abstract Previous studies (R. Endean et al. (1974), Toxicon12: 131–138) indicate that whole venom from the marine mollusc Conus geographus directly inhibits skeletal muscle, leaving peripheral nerves, cardiac and smooth muscle unaffected. A quantitative bioassay has been used to detect and measure biologically active myotoxin. By using chromatography
L J, Cruz, W R, Gray, B M, Olivera
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Specific In Vitro Biological Activity of Snake Venom Myotoxins
Journal of Neurochemistry, 1993Abstract: Some snake venoms contain toxins that are reported to be selective for damaging muscle. This specificity can be used to design experiments intended to eliminate muscle. We studied the small myotoxins and fractions IV and V of Bothrops nummifer venom to evaluate their direct effect on cultured muscle cells, neurons, macrophages, and a ...
J L, Brusés +3 more
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Detection of myotoxin a-like proteins in various snake venoms
Toxicon, 1988Ninety-five venom samples from eight snake genera (Agkistrodon, Bitis, Bothrops, Calloselasma, Crotalus, Sistrurus, Naja and Vipera) including venoms of Crotalus species of different geographical origin were assayed using immunodiffusion or an ELISA for the presence of the small basic protein, myotoxin alpha, known to cause muscle necrosis.
M A, Bober +3 more
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Purification of a myotoxin from the toadfish Thalassophryne maculosa (Günter) venom
Toxicon, 2005Venom was milked by gently pressing the base of the opercular and dorsal fin spines. Three fractions were obtained by molecular exclusion high pressure liquid chromatography (HPLC) (Protein Pak 125SW, Millipore Corporation) column, but only the last one with 22.7 min retention time (rt) was biological active (TmPP-22.7).
J I, Sosa-Rosales +4 more
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A common cytolytic region in myotoxins, hemolysins, cardiotoxins and antibacterial peptides*
International Journal of Peptide and Protein Research, 1989Several proteins and polypeptides of reptilian, amphibian, insect, and microbial origin share a common cytolytic property. However, these cytolysins fulfill different objectives. They provide offensive armament in the case of toxins, but defensive systems in the case of antibacterial peptides.
R M, Kini, H J, Evans
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Characterization of nicked myotoxin a and its effect on the sarcoplasmic reticulum calcium pump
Archives of Biochemistry and Biophysics, 1988Myotoxin a, a muscle-necrotizing polypeptide isolated from Crotalus viridis viridis (prairie rattlesnake) venom, was nicked at Met-28 by cyanogen bromide. Amino acid analysis indicated that the methionine content was reduced to zero from the original 1 mol.
N, Mori, A T, Tu, A, Maurer
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