Can anti-bothropstoxin-I antibodies discriminate between Bothrops jararaca and Bothrops jararacussu venoms? [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 Background Snakes of the genus Bothrops, popularly known as pit vipers, are responsible for most cases of snakebite in Brazil. Within this genus, Bothrops jararacussu and B.
Ricardo Teixeira Araujo +5 more
doaj +8 more sources
Bothrops jararacussu Venom Inactivated by High Hydrostatic Pressure Enhances the Immunogenicity Response in Horses and Triggers Unexpected Cross-Reactivity with Other Snake Venoms [PDF]
ToxinsHigh hydrostatic pressure (HHP) has been used for viral inactivation to facilitate vaccine development when immunogenicity is maintained or even increased. In this work, we used HHP to inactivate Bothrops jararacussu venom. Our protocol promotes the loss
Ricardo Teixeira-Araujo +5 more
doaj +3 more sources
A C-type lectin from Bothrops jararacussu venom disrupts Staphylococcal biofilms. [PDF]
PLoS ONE, 2015 Bovine mastitis is a major threat to animal health and the dairy industry. Staphylococcus aureus is a contagious pathogen that is usually associated with persistent intramammary infections, and biofilm formation is a relevant aspect of the outcome of ...
Raphael Contelli Klein +5 more
doaj +5 more sources
In Silico Evaluation of Quercetin Methylated Derivatives on the Interaction with Secretory Phospholipases A2 from Crotalus durissus terrificus and Bothrops jararacussu [PDF]
Pharmaceuticals, 2023 Quercetin derivatives have already shown their anti-inflammatory potential, inhibiting essential enzymes involved in this process. Among diverse pro-inflammatory toxins from snake venoms, phospholipase A2 is one of the most abundant in some species, such
Mariana Novo Belchor +8 more
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Brazilian Bothrops and Crotalus Snake Venoms as a Source of Antiprotozoal Agents: Unlocking Toxins for Therapeutic Development [PDF]
ToxinsLeishmaniasis and Chagas disease are neglected tropical diseases that continue to pose significant public health challenges, highlighting the need for new therapeutic strategies.
Tulio Custódio Reis +8 more
doaj +2 more sources
Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments. [PDF]
PLoS ONE, 2016 Antivenoms, produced using animal hyperimmune plasma, remains the standard therapy for snakebites. Although effective against systemic damages, conventional antivenoms have limited efficacy against local tissue damage.
Nidiane D R Prado +16 more
doaj +2 more sources
Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root extract on the local effects induced by Bothrops jararacussu venom [PDF]
Brazilian Journal of Medical and Biological Research, 2018 Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B.
N.T.Q. Alves +15 more
doaj +2 more sources
Exploiting exopolysaccharides from microalgae to block the toxic in vitro effects of Bothrops sp. venom [PDF]
Scientific ReportsSnakebite envenomation causes various toxic effects in humans, including death. Antivenoms are effectively prevent death but cannot completely block local muscle tissue damage, resulting in amputation and disability; thus, complementary therapies are ...
Camila Castro-Pinheiro +5 more
doaj +2 more sources
Heliyon, 2023 Snake envenomation is a neglected tropical disease. In Brazil, the Bothrops genus is responsible for about 86% of snakebite accidents. Despite extensive evidence of the cytotoxicity of snake venoms, the cellular and molecular mechanisms involved are not ...
Bianca Sayuri Takayasu +4 more
doaj +1 more source
Venomous snakes of medical importance in the Brazilian state of Rio de Janeiro: habitat and taxonomy against ophidism [PDF]
Brazilian Journal of Biology, 2023 Snakebite envenoming is a major global health problem that kills or disables half a million people in the world’s poorest countries. Identifying the biting snake and its habitat use is key to understanding snakebite eco-epidemiology and optimizing its ...
B. R. Duque +5 more
doaj +1 more source