Bothrops jararaca Snake Venom Inflammation Induced in Human Whole Blood: Role of the Complement System [PDF]
Frontiers in Immunology, 2022 The clinical manifestations of envenomation by Bothrops species are complex and characterized by prominent local effects that can progress to tissue loss, physical disability, or amputation. Systemic signs can also occur, such as hemorrhage, coagulopathy,
Carla Cristina Squaiella-Baptistão +2 more
exaly +4 more sources
Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation [PDF]
Scientific ReportsInoculation of Bothrops jararaca snake venom (BjV) induces thrombocytopenia in humans and various animal species. Although several BjV toxins acting on hemostasis have been well characterized in vitro, it is not known which one is responsible for ...
Marcelo Larami Santoro +10 more
doaj +4 more sources
Oral Tolerance Induction by Bothrops jararaca Venom in a Murine Model and Cross-Reactivity with Toxins of Other Snake Venoms [PDF]
Toxins, 2021 Oral tolerance is defined as a specific suppression of cellular and humoral immune responses to a particular antigen through prior oral administration of an antigen. It has unique immunological importance since it is a natural and continuous event driven
Lilian Rumi Tsuruta +3 more
doaj +2 more sources
Cationic PLGA Nanoparticle Formulations as Biocompatible Immunoadjuvant for Serum Production and Immune Response against Bothrops jararaca Venom [PDF]
Toxins, 2022 Snakebite envenoming represents a worldwide public health issue. Suitable technologies have been investigated for encapsulated recombinant or native proteins capable of inducing an effective and long-lasting adaptive immune response.
Emanuell dos Santos-Silva +7 more
doaj +2 more sources
Release of Cytokines in the Peritoneal Fluid of C57BL/6 Mice After Bothrops jararaca and Bothrops atrox Venom Injection [PDF]
ToxinsThe release of cytokines in the peritoneal fluid after stimulation with Bothrops atrox and Bothrops jararaca venoms is a crucial process in the inflammatory response triggered by these venoms.
Adriana da Silva Fernandes Ribas +4 more
doaj +2 more sources
In-depth transcriptome reveals the potential biotechnological application of Bothrops jararaca venom gland [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: Lack of complete genomic data of Bothrops jararaca impedes molecular biology research focusing on biotechnological applications of venom gland components.
Leandro de Mattos Pereira +9 more
doaj +2 more sources
Understanding Local Reactions Induced by Bothrops jararaca Venom: The Role of Inflammatory Mediators in Leukocyte–Endothelium Interactions [PDF]
BiomedicinesIn recent years, extensive research has delved into the pathophysiology of local reactions triggered by Bothrops snake venoms. Even though antivenom works well at reducing death and systemic effects, it is still not very effective in treating local ...
Bianca Cestari Zychar +1 more
doaj +2 more sources
Exploring the Venom Gland Transcriptome of Bothrops asper and Bothrops jararaca: De Novo Assembly and Analysis of Novel Toxic Proteins [PDF]
ToxinsPrevious proteomic studies of viperid venom revealed that it is mainly composed of metalloproteinases (SVMPs), serine proteinases (SVSPs), phospholipase A2 (PLA2), and C-type lectins (CTLs).
Joseph Espín-Angulo, Doris Vela
doaj +2 more sources
Proteomics and life-history variability of Endogenous Phospholipases A2 Inhibitors (PLIs) in Bothrops jararaca plasma. [PDF]
PLoS ONEIn Brazil, the genus Bothrops is responsible for most ophidian accidents. Snake venoms have a wide variety of proteins and peptides exhibiting a broad repertoire of pharmacological and toxic effects that elicit systemic injury and characteristic local ...
Caroline Serino-Silva +10 more
doaj +2 more sources
Effect of Seaweed-Derived Fucoidans from Undaria pinnatifida and Fucus vesiculosus on Coagulant, Proteolytic, and Phospholipase A2 Activities of Snake Bothrops jararaca, B. jararacussu, and B. neuwiedi Venom [PDF]
ToxinsBackground: Snakebite envenomation (SBE) causes diverse toxic effects in humans, including disability and death. Current antivenom therapies effectively prevent death but fail to block local tissue damage, leading to an increase in the severity of ...
Camila Castro-Pinheiro +7 more
doaj +2 more sources